A framework for the targeted selection of herbs with similar efficacy by exploiting drug repositioning technique and curated biomedical knowledge

Effects of Dipsacus asperoides and Phlomis umbrosa Extracts in a Rat Model of Osteoarthritis

“…Since the Nagoya Protocol came into force, the acquisition of traditional herbal medicines has become increasingly difficult, and the demand for alternative herbs with similar efficacy has increased, which has led to comparative studies of their effects [7,8]. The domestic use of D. asperoides depends on imports from China, whereas P. umbrosa is a Korean native herb, and its availability does not depend on imports.…”

“…Since the Nagoya Protocol came into force, there has been intense competition between countries to secure pre-emptive rights to state-owned indigenous resources; therefore, finding alternative herbs of similar efficacy to those used in traditional medicine is important [6]. Herbal resources are difficult to obtain, and there is increasing demand for alternative medicines of similar efficacy, which makes this an active area of research [7,8]. The identification of effective agents among Korean native herbal resources is ongoing.…”

Ameliorative potentials of Persea americana leaf extract on toxicants - induced oxidative assault in multiple organs of wistar albino rat

“…Medicinal plants have been recognized as veritable alternative to conventional drugs in the treatment of diseases [10][11][12]. Their vast medicinal importance is intrinsically linked to the presence of phytochemicals, which are synthesized primarily by plants for their protection against predators and other stressors in the ecosystem.…”

“…Their vast medicinal importance is intrinsically linked to the presence of phytochemicals, which are synthesized primarily by plants for their protection against predators and other stressors in the ecosystem. Phytochemicals have been exploited in the treatment of several pathological conditions [11], with proven capacity as potential therapeutic alternative in the treatment and/or management of diseases. Medicinal plants present a lot of advantages: they are readily available, biologically friendly (being natural), cost-effective and therapeutically potent [13,14].…”

Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of <i>P. americana</i> Leaf in Alloxan-Induced Diabetic Rats

“…It is projected by 2040 to become of the world's main disablers and killers, as the number of people with diabetes multiplies worldwide [5]. The World Health Organization has also recommended the evaluation of the effective use of plants, because the use of modern drugs is not safe [6] [7], with 70-80% of people worldwide use herb for management of mild to moderate illnesses [8][9][10]. The synthetic hypoglycemic agents used in clinical practices have serious side effects like haematological effects, coma, disturbances of liver and kidney [11,12,13].…”