A free-standing, sheet-shaped, “hydrophobic” biomaterial containing polymeric micelles formed from poly(ethylene glycol)-poly(lactic acid) block copolymer for possible incorporation/release of “hydrophilic” compounds

Moroishi, Hitomi; Yoshida, Chikara; Murakami, Yoshihiko

doi:10.1016/j.colsurfb.2012.08.050

Cited by 20 publications

(10 citation statements)

References 26 publications

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“…Moreover, a high amount of protein leads to an increase water-holding capacity due to the hydrophilic characteristics of proteins (Moroishi et al, 2013). Yu et al (2012) reported that the highest water absorption index values were associated with the highest levels of protein addition in corn flours.…”

Section: Water Absorption and Solubility Indices Instant Soup (Is)mentioning

confidence: 99%

Flours and Instant Soup from Tilapia Wastes as Healthy Alternatives to the Food Industry

Monteiro

Mársico

Torre

et al. 2014

FSTR

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The aim of this manuscript was to perform a nutritional and technological characterization of value-added products manufactured from tilapia wastes that have partial replacement potential for products commonly used by the food industry. All products displayed highest protein and ash content whereas lowest amount of carbohydrates compared with similar products already commercialized by the food industry. These products also displayed promising technological characteristics such as water absorption index (WAI), particle size average (PSA), water activity (Aw), and pH, which are relevant parameters for the elaboration of innovative food formulation. We concluded that instant soup and flours from tilapia wastes can be used in the food industry either for development and introduction of new food products on the market or for the replacement in current food products made from conventional flour sources, producing a healthy alternative on consumers.

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Section: Water Absorption and Solubility Indices Instant Soup (Is)mentioning

confidence: 99%

Flours and Instant Soup from Tilapia Wastes as Healthy Alternatives to the Food Industry

Monteiro

Mársico

Torre

et al. 2014

FSTR

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“…To achieve the successful incorporation and release of drugs, we have developed a novel approach for the construction of functional biomaterials. We have applied this approach to the chemical or physical conjugation of functional units (such as amphiphilic block copolymers or their self-assemblies) to base materials, including gels [21,22,23,24,25,26,27,28], sheets [29,30,31], and particles [32,33,34,35,36]. For example, the covalent incorporation of trilayered polymeric micelles [37,38] with hydrophilic inner cores into gels gave them the ability to release hydrophilic compounds [24].…”

Section: Introductionmentioning

confidence: 99%

PLA- and PLA/PLGA-Emulsion Composite Biomaterial Sheets for the Controllable Sustained Release of Hydrophilic Compounds

2018

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In the present study, by spin-coating a solution containing w/o (water-in-oil) emulsions and hydrophobic polymers, we obtained sheets possessing uniformly dispersed w/o emulsions. We performed release experiments for more than 100 days and clarified the effects of the number of layers, the sheet-forming polymers (polylactide (PLA), poly(lactic-co-glycolic acid (PLGA)), the ratio of organic solvent to water, and the composition of block copolymers on the release properties of the sheets. For a variety of sheets, we successfully achieved the sustained release of compounds from the sheets for 100–150 days. The sustained-release of compounds occurred because the compounds had to diffuse into polymer networks after their release from the emulsions. Interestingly, we observed an inflection point in the release profiles at around 50 days; that is, the sheet exhibited a “two-step” release behavior. The results obtained in the present study provide strong evidence for the future possibility of the time-programmed release of multiple compounds from sheets.

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“…Many studies have shown that polymeric micelles have the ability to improve solubility, oral absorption, bioavailability, and pharmacological effect of hydrophobic drug [ 10 , 15 , 16 ]. Methoxy poly(ethylene glycol)- b -poly(L-lactic acid) (MPEG- b -PLLA) is one of the amphiphilic copolymers and it could be used to form micelles to encapsulate many drugs [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Quercetin-Loaded Methoxy Poly(ethylene glycol)-b-poly(L-lactic acid) Micelle after Oral Administration in Rats

Liu

et al. 2017

BioMed Research International

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The purpose of this study was to evaluate the potential of micelle to change the pharmacokinetics of quercetin (QUT), with a primary goal of enhancing its oral bioavailability. QUT-loaded methoxy poly(ethylene glycol)-b-poly(L-lactic acid) micelle (QUT-loaded MPEG-b-PLLA micelle) was prepared by a thin-film hydration method, resulting in a particle size of 88.5 nm. A liquid chromatography tandem-mass spectrometry (LC-MS/MS) method was developed and validated for determination of QUT in rat plasma. The chromatographic separation was performed on an Agilent Eclipse-C18 (4.6 mm × 50 mm, 3.5 μm) with an isocratic mobile phase system consisting of water and methanol (30 : 70, v/v) at a flow rate of 0.4 mL/min. Calibration curves were linear over the concentration ranges of 2.5–2000 ng/mL for QUT. The micelle was orally administered at a single does in rats, and the pharmacokinetic parameters were evaluated and compared with that administered with the QUT aqueous suspension. The results show that the micelle was able to increase the QUT's oral bioavailability 9-fold compared to the QUT aqueous suspension. These results suggest that methoxy poly(ethylene glycol)-b-poly(L-lactic acid) is a potential carrier for the oral delivery of QUT.

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A free-standing, sheet-shaped, “hydrophobic” biomaterial containing polymeric micelles formed from poly(ethylene glycol)-poly(lactic acid) block copolymer for possible incorporation/release of “hydrophilic” compounds

Cited by 20 publications

References 26 publications

Flours and Instant Soup from Tilapia Wastes as Healthy Alternatives to the Food Industry

Flours and Instant Soup from Tilapia Wastes as Healthy Alternatives to the Food Industry

PLA- and PLA/PLGA-Emulsion Composite Biomaterial Sheets for the Controllable Sustained Release of Hydrophilic Compounds

Pharmacokinetics of Quercetin-Loaded Methoxy Poly(ethylene glycol)-b-poly(L-lactic acid) Micelle after Oral Administration in Rats

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