A FRET-based ratiometric fluorescent and colorimetric probe for the facile detection of organophosphonate nerve agent mimic DCP

Abstract

A FRET ratiometric fluorescent probe enabling a fast and highly sensitive response to OP nerve agent mimic DCP within 1 min and with as low as 0.17 ppm concentration detection limit has been developed. Moreover, the probe exhibits noticeable color changes under UV light and even with the naked eye. It is also demonstrated that it can detect both liquid and gas nerve agents.

A novel FRET-based ratiometric fluorescent probe for highly sensitive detection of hydrogen sulfide

“…23 The FRET dyad CR was prepared by the condensation of carboxyl compound 7 with amide 8. The coumarin donor building block 7 and rhodamine/fluorescein acceptor building block 8 were synthesized by a reported synthetic procedure.…”

Sensitive fluorescence on-off probes for the fast detection of a chemical warfare agent mimic

“…Likewise, many of these problems can be overcome using optical sensors and notably fluorescence probes are emerging as suitable alternatives due to their ease of handling, low cost and high sensitivity [16][17][18][19][20][21].…”

A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals

“…(2) Arigid piperazine linker was used to bridge the two fluorophores and provided an advantage for Fçrster resonance energy transfer (FRET) in the coumarin-rhodol scaffold, which preventing the p-p stacking between dyes. [13] (3) Azidation of coumarin and phenyl 2-(benzoylthio)benzoate-protected rhodol should effectively quench the fluorescence of the probe via the intramolecular charge transfer (ICT) effect and the intramolecular spirocyclization, respectively.T he probe should bear very low background fluores-cence that is favorable for high sensitivity. ( 4) Thea zide and phenyl 2-(benzoylthio)benzoate moieties provide selective reaction sites for H 2 Sand H 2 S n .…”