A Fruitful Decade of Organofluorine Chemistry: New Reagents and Reactions

Superbase-Mediated gem-Difluoroalkenylations of Sulfoximines

“…Sulfoximines have been identified as relevant for medicinal and crop protection chemistry . As in other molecules, fluoro substituents significantly affect the properties of sulfoximines . While most fluorinated sulfoximines are rather stable, some rapidly react by selective S–C bond cleavage, allowing for their use, for example, as highly effective electrophilic fluoroalkylating agents .…”

Construction of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides and derivatives

“…Trifluoromethyl-containing heterocycles have received increasing attention due to their wide prevalence in natural products, pharmaceuticals, agrochemicals, functional materials, and biologically active molecules. 1 It is well-known that the incorporation of a trifluoromethyl group into organic scaffolds could improve the physicochemical and pharmacokinetic properties and modulate p K a and lipophilicity of the parent molecules. 2 Notably, approximately 25% of marketed drugs and 30% of agrochemical products contain at least one fluorine or trifluoromethyl moiety, such as mavacoxib, efavirenz, melatonin, sitagliptin, pentoxifylline, and so on (Fig.…”

Catalyst-free electrochemical trifluoromethylation of coumarins using CF3SO2NHNHBoc as the CF3 source

“…14 Trifluoromethylated compounds have widespread applications in the pharmaceutical and agrochemical industries, and as functional materials. [15][16][17] Meanwhile, novel trifluoromethylation reagents and creative trifluoromethylation methods 18,19 have also been extensively developed. In this context, the introduction of the trifluoromethyl group into coumarins is of great interest for both organic and medicinal communities.…”