A FSI computational framework for vascular physiopathology: A novel flow-tissue multiscale strategy

Bianchi, Daniele; Monaldo, Elisabetta; Gizzi, Alessio; Marino, Michele; Filippi, Sandra; Vairo, Giuseppe

doi:10.1016/j.medengphy.2017.06.028

Cited by 34 publications

(18 citation statements)

References 55 publications

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“…Generalizing the early ideas by Lanir on microstructural‐based models, the multiscale structural constitutive model allocates macroscopic stress to a number of microstructural and nanostructural mechanisms and allows to introduce parameters corresponding to measurable structural properties. The effectiveness of this approach has been confirmed by comparisons with experimental data() and by applications in advanced case studies . On the basis of this constitutive approach, a statistically relevant quantitative correlation is here traced between biomechanical output quantities (eg, tissue stress function, low‐ and high‐strain tangent moduli, transition stress and strain, and internal deformation modes) and input parameters representing collagen‐related structural and biochemical features (ie, fiber crimp amplitude and thickness, density of intermolecular cross‐links, and molecular persistence length).…”

Section: Introductionmentioning

confidence: 80%

“…The effectiveness of this approach has been confirmed by comparisons with experimental data 2,31 and by applications in advanced case studies. 32 On the basis of this constitutive approach, a statistically relevant quantitative correlation is here traced between biomechanical output quantities (eg, tissue stress function, low-and high-strain tangent moduli, transition stress and strain, and internal deformation modes) and input parameters representing collagen-related structural and biochemical features (ie, fiber crimp amplitude and thickness, density of intermolecular cross-links, and molecular persistence length). Therefore, sensitivity analysis is firstly performed to identify the key input parameters affecting the relationship between tissue structure and mechanics.…”

Section: Figurementioning

confidence: 99%

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Sensitivity analysis for the mechanics of tendons and ligaments: Investigation on the effects of collagen structural properties via a multiscale modeling approach

Hamdia

Marino

Zhuang

et al. 2019

Numer Methods Biomed Eng

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The effects of the stochasticity of collagen‐related structural properties on the biomechanical properties of tendons and ligaments are investigated in this study. The tissue mechanics is modeled by means of a macroscale constitutive model based on a multiscale structural approach. This rationale allows to introduce model parameters directly associated with tissue structural and biochemical features, opening to physically motivated parametric studies. Variance and density‐based global sensitivity analyses are employed, together with the quantification of output uncertainty due to stochastic variations of parameters. Novel insights on tissue structure‐mechanics relationship are provided, quantifying the dependence between mechanical output quantities on specific collagen‐related structural features. Moreover, the uncertainty quantification shows that model predictions provided by the multiscale structural approach are reliable with respect to inevitable uncertainties in tissue structure. Addressing rat tail tendons, the use of average values in tissue properties returns a constitutive response that fits well‐available experimental data, and it is robust with respect to parameter stochasticity.

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Section: Introductionmentioning

confidence: 80%

Section: Figurementioning

confidence: 99%

Sensitivity analysis for the mechanics of tendons and ligaments: Investigation on the effects of collagen structural properties via a multiscale modeling approach

Hamdia

Marino

Zhuang

et al. 2019

Numer Methods Biomed Eng

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“…Future studies will address some limitations of the present work that can be straightforwardly incorporated by means of well-established approaches: the active contraction of SMCs and the unsteady effects due to fluid-structure interaction have not been considered [26,62]; possible damage and repair of ECM constituents have been neglected [24]; the mass growth and the natural turnover of ECM constituents have not been addressed [28,29], making it impossible to analyse ageing mechanisms, such as collagen production in response to progressive elastin lost [63]; no distinction has been made between latent and active concentrations or between pro-and anti-inflammatory forms of molecular species [25]; arterial geometry is idealized and only the media layer is addressed [32,64]; and the dispersed distribution of collagen fibres in tissues is simplified with respect to recent evidence on non-symmetric distributions [65,66].…”

Section: Discussionmentioning

confidence: 99%

A chemo-mechano-biological formulation for the effects of biochemical alterations on arterial mechanics: the role of molecular transport and multiscale tissue remodelling

Marino

Pontrelli

Vairo

et al. 2017

J. R. Soc. Interface.

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This paper presents a chemo-mechano-biological framework for arterial physiopathology. The model accounts for the fine remodelling in the multiscale hierarchical arrangement of tissue constituents and for the diffusion of molecular species involved in cell-cell signalling pathways. Effects in terms of alterations in arterial compliance are obtained. A simple instructive example is introduced. Although oversimplified with respect to realistic case studies, the proposed application mimics the biochemical activity of matrix metalloproteinases, transforming growth factors beta and interleukins on tissue remodelling. Effects of macrophage infiltration, of intimal thickening and of a healing phase are investigated, highlighting the corresponding influence on arterial compliance. The obtained results show that the present approach is able to capture changes in arterial mechanics as a consequence of the alterations in tissue biochemical environment and cellular activity, as well as to incorporate the protective role of both autoimmune responses and pharmacological treatments.

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“…The nontrivial vascular wall structure requires a constitutive model that can reproduce mechanical behavior under various internal and external pressures during FSI simulations . When considering the issues involving FSI, oversimplified constitutive models will impede the results of structural and fluid flow domains.…”

Section: Methodsmentioning

confidence: 99%

A comparative study of methods used to generate the arterial fiber structure in a clinically relevant numerical analysis

Misiulis

Džiugys

Navakas

et al. 2019

Numer Methods Biomed Eng

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The advanced constitutive material models of artery wall require the definition of the mean collagen fiber directions in the material configuration. There are several proposed methods; however, it is unclear how much does the fiber structures obtained by these methods differ one from the other and how much this difference may affect the results of the structural analysis of a clinically relevant scenario. Therefore, in this paper, we address this issue by presenting the results of the comparative study of our developed and currently state-of-the-art fiber definition methods. In addition, we present the verification of our developed numerical model that incorporates the extended Holzapfel-Gasser-Ogden (HGO) constitutive material model and the generalized prestressing algorithm (GPA). In the case of the patient-specific internal carotid artery (ICA), the percentage error of the mean fiber directions defined by different methods does not exceed 17.73% (at least 0.05%, at most 81.82%) and has negligible effect on the stress levels, as the percentage error of the mean circumferential Cauchy stress does not exceed 0.1%. Both fiber definition methods produce comparable fiber structure, but our proposed method has an advantage, as it does not depend on method and software used to model the arterial wall mechanics.

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A FSI computational framework for vascular physiopathology: A novel flow-tissue multiscale strategy

Cited by 34 publications

References 55 publications

Sensitivity analysis for the mechanics of tendons and ligaments: Investigation on the effects of collagen structural properties via a multiscale modeling approach

Sensitivity analysis for the mechanics of tendons and ligaments: Investigation on the effects of collagen structural properties via a multiscale modeling approach

A chemo-mechano-biological formulation for the effects of biochemical alterations on arterial mechanics: the role of molecular transport and multiscale tissue remodelling

A comparative study of methods used to generate the arterial fiber structure in a clinically relevant numerical analysis

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