We consider the fourth-order Schrödinger equationwhere α > 0, µ = ±1 or 0 and λ ∈ C. Firstly, we prove local well-posedness in H 4 R N in both H 4 subcritical and critical case: α > 0, (N − 8)α ≤ 8. Then, for any given compact set K ⊂ R N , we construct H 4 (R N ) solutions that are defined on (−T, 0) for some T > 0, and blow up exactly on K at t = 0.