A fully biocompatible single-mode distributed feedback laser

Choi, Yunkyoung; Jeon, Heonsu; Kim, Sunghwan

doi:10.1039/c4lc01171f

Cited by 43 publications

(34 citation statements)

References 23 publications

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“…[7,8] WGM lasers made of polymers of biological origin are of interest for biosensing. To date, various biolasers have been investigated using random cavity, [9][10][11][12][13] distributed feedback, [14][15][16] Fabry-Perot (F-P), [17][18][19] and WGM capillary tube. [20] Generally, current devices are large (>>100 µm) and mainly rely on a time was 10, 60, 90 min for BSA, pectin, cellulose spheres, respectively.…”

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confidence: 99%

Microsphere Solid‐State Biolasers

Caixeiro

Fernandes

et al. 2017

Advanced Optical Materials

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Biolasers obtained from biomaterials are attracting a wealth of interest for their potential as future biosensors with enhanced sensitivity, and advanced cell tracking. Here, miniature biolasers are reported, which are formed by bovine serum albumin (BSA) protein and biosourced polysaccharides derived from land plants such as cellulose and pectin. Using a green processing route aided by simple emulsions, solid-state microspheres with diameters of 15–100 µm are fabricated and utilized as whispering gallery mode lasers with thresholds of a few µJ mm–2 and quality factors of up to 3000. Furthermore, BSA microlasers are found to be compatible with cell growth and resistant to the aqueous environment of cell culture media. This environmentally friendly and biocompatible design shows promise for future implantable biosensing devices opening a path between laser science and medicine

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confidence: 99%

Microsphere Solid‐State Biolasers

Caixeiro

Fernandes

et al. 2017

Advanced Optical Materials

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“…Lasers made entirely from biomaterials were also demonstrated. For example, a distributed feedback laser (DFB) was made from riboflavin doped gelatin [12] and silk [13], and whispering-gallery-mode (WGM) lasing has been achieved in water droplets [14,15] and protein microspheres [16]. …”

Section: Introductionmentioning

confidence: 99%

Biomaterial microlasers implantable in the cornea, skin, and blood

Humar

Dobravec

Zhao

et al. 2017

Optica

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Stand-alone laser particles that are implantable into biological tissues have potential to enable novel optical imaging, diagnosis and therapy. Here we demonstrate several types of biocompatible microlasers and their lasing action within biological systems. Dye-doped polystyrene beads were embedded in the cornea and optically pumped to generate narrowband emission. We fabricated microbeads with poly(lactic-co-glycolic acid) and poly(lactic acid)—substances approved for medical use—and demonstrate lasing from within tissues and whole blood. Furthermore, we demonstrate biocompatible cholesterol-derivative microdroplet lasers via self-assembly to an onion-like radially-resonant photonic crystal structure.

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“…For example, a LOD as low as 26 pg/mL have been obtained for the ErbB2 biomarker in diluted human serum samples using a highly sensitive amperometric magnetoimmunosensor [19]. However, DFB laser biosensing represents a cost-effective way to detect biomolecules and the DFB laser can be made entirely in polymer [20] or even be completely biocompatible [21]. It can lead to its use not only as an in-vitro diagnostic tool if not as an in-vivo biosensor for in-situ detection of biomolecules.…”

Section: Insert Figurementioning

confidence: 99%