A fully implantable wireless bidirectional neuromodulation system for mice

Wright, Jason; Mughrabi, Ibrahim; Wong, Jason; Mathew, Jose; Jayaprakash, Naveen; Crosfield, Christine; Chang, Eric H.; Chavan, Sangeeta; Tracey, Kevin J.; Pavlov, Valentin A.; Al‐Abed, Yousef; Zanos, Theodoros P.; Zanos, Stavros; Datta-Chaudhuri, Timir

doi:10.1016/j.bios.2021.113886

Cited by 28 publications

(13 citation statements)

References 57 publications

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“…sources (Iyer et al, 2022), is promising, but also depends on the experimental paradigm and access to the animal (Kim et al, 2021;Wright et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

An implantable neurophysiology platform: Broadening research capabilities in free-living and non-traditional animals

Gaidica

Dantzer²

2022

Front. Neural Circuits

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Animal-borne sensors that can record and transmit data (“biologgers”) are becoming smaller and more capable at a rapid pace. Biologgers have provided enormous insight into the covert lives of many free-ranging animals by characterizing behavioral motifs, estimating energy expenditure, and tracking movement over vast distances, thereby serving both scientific and conservational endpoints. However, given that biologgers are usually attached externally, access to the brain and neurophysiological data has been largely unexplored outside of the laboratory, limiting our understanding of how the brain adapts to, interacts with, or addresses challenges of the natural world. For example, there are only a handful of studies in free-living animals examining the role of sleep, resulting in a wake-centric view of behavior despite the fact that sleep often encompasses a large portion of an animal’s day and plays a vital role in maintaining homeostasis. The growing need to understand sleep from a mechanistic viewpoint and probe its function led us to design an implantable neurophysiology platform that can record brain activity and inertial data, while utilizing a wireless link to enable a suite of forward-looking capabilities. Here, we describe our design approach and demonstrate our device’s capability in a standard laboratory rat as well as a captive fox squirrel. We also discuss the methodological and ethical implications of deploying this new class of device “into the wild” to fill outstanding knowledge gaps.

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“…sources (Iyer et al, 2022), is promising, but also depends on the experimental paradigm and access to the animal (Kim et al, 2021;Wright et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

An implantable neurophysiology platform: Broadening research capabilities in free-living and non-traditional animals

Gaidica

Dantzer²

2022

Front. Neural Circuits

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“…a) Examples of primary categories used for encapsulation of implantable devices. From left to right: Wireless bidirectional neuromodulation system for mice . Reproduced with permission.…”

Section: Biointegration Strategies For Implantable Devicesmentioning

confidence: 99%

Wireless Battery-free and Fully Implantable Organ Interfaces

Bhatia,

Hanna,

Stuart

et al. 2024

Chem. Rev.

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Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting in a new generation of fully implantable organ interfaces that leverage volumetric reduction and soft mechanics by eliminating electrochemical power storage. This device class offers the ability to provide high-fidelity readouts of physiological processes, enables stimulation, and allows control over organs to realize new therapeutic and diagnostic paradigms. Driven by seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key to advances are carefully designed material, electrophysical, electrochemical, and electromagnetic systems that form implantables with mechanical properties closely matched to the target organ to deliver functionality that supports high-fidelity sensors and stimulators. The elimination of electrochemical power supplies enables control over device operation, anywhere from acute, to lifetimes matching the target subject with physical dimensions that supports imperceptible operation. This review provides a comprehensive overview of the basic building blocks of battery-free organ interfaces and related topics such as implantation, delivery, sterilization, and user acceptance. State of the art examples categorized by organ system and an outlook of interconnection and advanced strategies for computation leveraging the consistent power influx to elevate functionality of this device class over current battery-powered strategies is highlighted.

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“…Electrical stimulation is most common for neural modulations for nerve stimulation, ,, deep brain stimulation (DBS), , and VNS. , Electric currents with tunable amplitudes, frequencies, and frequency bandwidths evoke responses when applied to the targeted tissues. The parameters for stimulating electrical signals vary across applications, but generally, short pulse durations in the range of microseconds (μs) are commonly used to minimize tissue damages .…”

Section: Brain–computer Interface For Modulation and Sensingmentioning

confidence: 99%

Convergence of Implantable Bioelectronics and Brain–Computer Interfaces

Huynh,

Nguyen,

Nguyen

et al. 2023

ACS Appl. Electron. Mater.

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Missing neuronal communication between parts of the body and the brain can cause organ failures or life-threatening conditions including cardiovascular and neurological diseases. The implantable brain−computer interface (BCI) is an emerging interdisciplinary technology that can bridge the communication gap, restoring organ functions and treating neurological disorders. Since the success of the first battery-powered pacemaker in 1958, bioelectronics technology has made a prodigious leap toward a wide range of biomedical applications such as therapeutics, diagnostics, and assistive organ implants. The latest developments in material sciences and device integrations have enabled a technological paradigm shift from rigid to soft and mechanically conformal implantable BCI devices that could eliminate device−tissue mismatches. However, achieving mechanical and electrical stability with organic-and nanomaterial-based electronics implanted in the body is a big challenge. Recent advances in inorganic and wide bandgap materials for BCI devices provide a promising route to solve this bottleneck due to their stability, modalities, and standardized manufacturing processes. Nevertheless, several remaining key obstacles still hinder the applications of soft BCI devices. This review summarizes the latest developments and key challenges of this emerging field, focusing on technological and scientific aspects such as materials, device structures, modulation, sensing, power, and communication. Current challenges and future perspectives of this emerging technology will also be discussed.

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A fully implantable wireless bidirectional neuromodulation system for mice

Cited by 28 publications

References 57 publications

An implantable neurophysiology platform: Broadening research capabilities in free-living and non-traditional animals

An implantable neurophysiology platform: Broadening research capabilities in free-living and non-traditional animals

Wireless Battery-free and Fully Implantable Organ Interfaces

Convergence of Implantable Bioelectronics and Brain–Computer Interfaces

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