Archaeological research, for several decades, has shown that various microblade technologies using obsidian and hard shale appeared and developed from the Last Glacial Maximum to the terminal Pleistocene (Bølling–Allerød–Younger Dryas) in Hokkaido, Northern Japan. It is well accepted that microblade technology was closely related to the high mobility of foragers to adapt to harsh environments. Recent archaeological and palaeoenvironmental evidence from Hokkaido demonstrates that the disappearance of microblade technology occurred during the terminal Pleistocene, influenced by a wide range of factors, including changes in landscape, climate, subsistence and human populations. The goal of this paper is to provide an overview of the current state of research on the process and background of the disappearance of microblade technology and to discuss prospects for future research. This paper will (1) review palaeoenvironmental research in Hokkaido on changes in climate and biological composition from the terminal Pleistocene to the initial Holocene; (2) survey changes in the technological adaptations and resource use of humans based on the archaeological evidence; and (3) discuss how the abrupt fluctuations of climate that occurred in the terminal Pleistocene affected human behaviour and demographics in Hokkaido.