A functional magnetic resonance imaging study on the effect of acupuncture at GB34 (Yanglingquan) on motor-related network in hemiplegic patients

Chen, Xing; Zhang, Hua; Zou, Yihuai

doi:10.1016/j.brainres.2015.01.011

Cited by 25 publications

(14 citation statements)

References 33 publications

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“…Previous studies have shown the crucial role of motor and cognitive-related regions and networks in the brain reorganization [9,[12][13][14], but ignored the fact that the two hemispheres always work as a whole. From the perspective of bilateral cerebral connections, combined with changes in function and structure, figuring out what happens after unilateral cerebral infarction, is much closer to the distribution and integration of motor function in the actual operation, which can better illustrate the central mechanism of acupuncture treatment.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture for poststroke hemiplegia focusing on bilateral cerebral connections: study protocol for a randomized controlled trial

Jiang

Geng

et al. 2019

Preprint

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Background: Acupuncture is safe and effective for improving the motor function of poststroke hemiplegic patients, but there still exists a certain gap between clinical practice and its neural mechanisms. The cerebral functional reconstruction after unilateral motor pathway injury exhibits a bilateral tendency, however current studies seldom pay attention to it. Hence, based on bilateral cerebral connections, the underlying mechanism of acupuncture in stroke rehabilitation remains research space to date. Methods: This is a single-center, randomized controlled, paralleled neuroimaging trial, with patients, outcome assessors, and data statisticians blinded. Stroke patients with motor dysfunction meeting the inclusion criteria will be randomly assigned (2:1) to receive either true acupoints treatment or sham acupoints treatment (5 sessions per week for 2 weeks). All the patients will receive conventional treatment and rehabilitation. Participants will undergo the neuroimaging scanning before and after the entire acupuncture treatment. The clinical primary outcomes are Fugl-Meyer assessments (FMA) and the National Institutes of Health stroke scales (NIHSS). The secondary outcome is Needle Sensation Assessment Scale (NSAS). The neuroimaing outcomes are voxel-mirrored homotopic connectivity (VMHC), fractional anisotropy (FA) and gray matter volume (GMV). The correlation analysis will be explored between the neuroimage indicators and clinical motor assessments. Discussion: From the perspective of bilateral connection, this trial will investigate the cerebral influence of acupuncture treatment on poststroke patients with motor dysfunction, promoting application of acupuncture in stroke rehabilitation. Trial registration: Chinese Clinical Trials Registry, ChiCTR 1800016263. Registered on 22 May, 2018.

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Section: Introductionmentioning

confidence: 99%

Acupuncture for poststroke hemiplegia focusing on bilateral cerebral connections: study protocol for a randomized controlled trial

Jiang

Geng

et al. 2019

Preprint

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“…Moreover, acupuncture at Waiguan (TE5) could modulate the SMN of the bilateral hemispheres and increase cooperation of bilateral SMNs in stroke patients (Chen J. et al, 2014). Our previous studies also demonstrated that acupuncture at GB34 could modulate the rsFC within the DMN, and showed positive interaction effect in ipsilesional motor-related cortices and negative interaction effect in contralesional motor cortex (Zhang Y. et al, 2014; Chen et al, 2015). Hence, our results of the current study provided new evidence that acupuncture could accelerate the neural plasticity of motor function by enhancing the rsFC of the bilateral M1s after subcortical stroke.…”

Section: Discussionmentioning

confidence: 74%

“…A previous study on task related fMRI had revealed that needling at GB34 could induce some motor related brain regions overlapped key regions of the sensorimotor network (SMN; Na et al, 2009). Our previous studies also had confirmed that needling at GB34 in hemiplegic patients could increase motor-cognition connectivity as well as decrease contralesional compensation of M1 and enhance the (FC) of the default mode network (DMN; Zhang Y. et al, 2014; Chen et al, 2015). However, little is known about the changes of FC between the bilateral M1s with respect to acupuncture therapy after subcortical stroke.…”

Section: Introductionmentioning

confidence: 61%

Enhanced Functional Connectivity between the Bilateral Primary Motor Cortices after Acupuncture at Yanglingquan (GB34) in Right-Hemispheric Subcortical Stroke Patients: A Resting-State fMRI Study

Ning

et al. 2017

Front. Hum. Neurosci.

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Increasing neuroimaging researches in stroke rehabilitation had revealed the neural mechanisms of rehabilitation therapy. However, little was known about the neural mechanisms of acupuncture therapy in subcortical stroke patients. The aim of this study was to investigate the changes of functional connectivity (FC) between the bilateral primary motor cortices (M1s) after acupuncture intervention in right subcortical stroke patients. Twenty right-hemispheric subcortical stroke patients and 20 healthy subjects were recruited to undergo one functional magnetic resonance imaging (fMRI) scanning. The scanning consisted of resting-state fMRI before and after needling at Yanglinquan (GB34), and task-evoked fMRI. The most significant active point during the left passive thumb-to-index task was chosen as the seed point. The seed-based FC analysis of the bilateral M1s was performed. Stroke patients revealed decreased FC between the bilateral M1s compared with healthy subjects, and the decreased FC was significantly enhanced after acupuncture at GB34. Acupuncture could increase the intrinsically decreased FC between the bilateral M1s which provided further insight into the neural mechanisms of acupuncture for motor function recovery in stroke patients.

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“…[ 14 ] The medial temporal lobe and posterior cingulate cortex (PCC) were the main node of DMN, which was further divided into 2 subnetworks (aDMN and pDMN) coparticipating in information integration and modulation. [ 46 ] FPN is halfway between DMN and DAN, and mainly involved in cognition controlling function such as memory, attention, and visual processing by the 2 mirroring networks (LFPN and RFPN). [ 47 , 48 ] Superior parietal lobule is considered to be the core of the network nodes.…”

Section: Discussionmentioning

confidence: 99%

Altered effective connectivity of resting state networks by acupuncture stimulation in stroke patients with left hemiplegia

Ning

et al. 2017

Medicine

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A functional magnetic resonance imaging study on the effect of acupuncture at GB34 (Yanglingquan) on motor-related network in hemiplegic patients

Cited by 25 publications

References 33 publications

Acupuncture for poststroke hemiplegia focusing on bilateral cerebral connections: study protocol for a randomized controlled trial

Acupuncture for poststroke hemiplegia focusing on bilateral cerebral connections: study protocol for a randomized controlled trial

Enhanced Functional Connectivity between the Bilateral Primary Motor Cortices after Acupuncture at Yanglingquan (GB34) in Right-Hemispheric Subcortical Stroke Patients: A Resting-State fMRI Study

Altered effective connectivity of resting state networks by acupuncture stimulation in stroke patients with left hemiplegia

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