A functional MRI study of somatotopic representation of somatosensory stimulation in the cerebellum

Takanashi, Mayako; Abe, Kazuo; Yanagihara, Takehiko; Sakoda, Saburo; Tanaka, Hisashi; Hirabuki, Norio; Nakamura, Hajime; Fujita, Norihiko

doi:10.1007/s00234-002-0935-3

Cited by 31 publications

(29 citation statements)

References 13 publications

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“…A study using electrical stimulation of the lower extremities [Smith et al, 2003], reported that afferent spinocerebellar information from muscle, joint and tactile receptors is important for the preparation and correction of ongoing movement. Takanashi et al [2003], using also electrical stimulation demonstrated a similar somatotopical organization within the cerebellum. We conclude that the observed cerebellar activation pattern in our study has been elicited by the passive movement, as well as by the electrical stimulation itself.…”

Section: Figurementioning

confidence: 69%

Cortical and subcortical correlates of functional electrical stimulation of wrist extensor and flexor muscles revealed by fMRI

Blickenstorfer¹,

Kleiser²,

Keller³

et al. 2008

Human Brain Mapping

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The main scope of this study was to test the feasibility and reliability of FES in a MR-environment. Functional Electrical Stimulation (FES) is used in the rehabilitation therapy of patients after stroke or spinal cord injury to improve their motor abilities. Its principle lies in applying repeated electrical stimulation to the relevant nerves or muscles for eliciting either isometric or concentric contractions of the treated muscles. In this study we report cerebral activation patterns in healthy subjects undergoing fMRI during FES stimulation. We stimulated the wrist extensor and flexor muscles in an alternating pattern while BOLD-fMRI was recorded. We used both block and event-related designs to demonstrate their feasibility for recording FES activation in the same cortical and subcortical areas. Six out of fifteen subjects repeated the experiment three times within the same session to control intraindividual variance. In both block and event-related design, the analysis revealed an activation pattern comprising the contralateral primary motor cortex, primary somatosensory cortex and premotor cortex; the ipsilateral cerebellum; bilateral secondary somatosensory cortex, the supplementary motor area and anterior cingulate cortex. Within the same subjects we observed a consistent replication of the activation pattern shown in overlapping regions centered on the peak of activation. Similar time course within these regions were demonstrated in the event-related design. Thus, both techniques demonstrate reliable activation of the sensorimotor network and eventually can be used for assessing plastic changes associated with FES rehabilitation treatment.

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Section: Figurementioning

confidence: 69%

Cortical and subcortical correlates of functional electrical stimulation of wrist extensor and flexor muscles revealed by fMRI

Blickenstorfer¹,

Kleiser²,

Keller³

et al. 2008

Human Brain Mapping

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“…30.2; Nitschke et al 1996;Bushara et al 2001;Grodd et al 2001Grodd et al , 2005; see also Takanashi et al 2003;Thickbroom et al 2003). The upside-down somatotopic representation in the anterior lobe has been confirmed in humans: leg and foot sensorimotor representations are localized to lobules II and III (Nitschke et al 1996), hand representations are in lobule V (e.g., Bushara et al 2001;Grodd et al 2001), and orofacial movements activate medial regions of lobule VI (Urban et al 2003;Dresel et al 2005).…”

Section: Activation During Sensorimotor Tasksmentioning

confidence: 84%

Functional Topography of the Human Cerebellum Revealed by Functional Neuroimaging Studies

Stoodley

Desmond²,

Schmahmann

2013

Handbook of the Cerebellum and Cerebellar Disorders

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Functional imaging studies in healthy subjects report cerebellar activation during a wide range of tasks, from motor execution (finger tapping, motor learning, smooth pursuit eye movements) to higher-level cognitive tasks (Tower of London, working memory paradigms, verbal fluency) in which motor responses are eliminated or controlled for. The anatomical connections between the cerebellum, spinal cord, and sensorimotor and association areas of the cerebral cortex suggest a functional topography exists within the human cerebellum, such that different cerebellar regions are part of distributed spinocerebellar and cerebro-cerebellar circuits. This concept is supported by data from functional imaging studies, in which regional activation patterns differ for sensorimotor vs. cognitive and affective task paradigms. Here these neuroimaging data are reviewed and both cross-task comparisons and within-task topography are considered. The evidence indicates that cerebellar activation patterns are related to the specific demands of a given task, and the localization of the activation patterns reflects the engagement of different cerebro-cerebellar circuits.

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“…A previous study using lower extremity electrical stimulation indicated that afferent spinocerebellar information from muscles, joints, and tactile receptors is important for the preparation and correction of ongoing movement [22]. Takanashi et al [23] also demonstrated a similar somatotopical organization within the cerebellum after electrical stimulation. It is conceivable that the cerebellar activation pattern observed in the present study was elicited by passive movement, as well as by the electrical stimulation itself.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of the brain activation induced by functional electrical stimulation and voluntary contraction using functional magnetic resonance imaging

Joa

Han

Mun

et al. 2012

J NeuroEngineering Rehabil

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BackgroundTo observe brain activation induced by functional electrical stimulation, voluntary contraction, and the combination of both using functional magnetic resonance imaging (fMRI).MethodsNineteen healthy young men were enrolled in the study. We employed a typical block design that consisted of three sessions: voluntary contraction only, functional electrical stimulation (FES)-induced wrist extension, and finally simultaneous voluntary and FES-induced movement. MRI acquisition was performed on a 3.0 T MR system. To investigate activation in each session, one-sample t-tests were performed after correcting for false discovery rate (FDR; p < 0.05). To compare FES-induced movement and combined contraction, a two-sample t-test was performed using a contrast map (p < 0.01).ResultsIn the voluntary contraction alone condition, brain activation was observed in the contralateral primary motor cortex (MI), thalamus, bilateral supplementary motor area (SMA), primary sensory cortex (SI), secondary somatosensory motor cortex (SII), caudate, and cerebellum (mainly ipsilateral). During FES-induced wrist movement, brain activation was observed in the contralateral MI, SI, SMA, thalamus, ipsilateral SII, and cerebellum. During FES-induced movement combined with voluntary contraction, brain activation was found in the contralateral MI, anterior cingulate cortex (ACC), SMA, ipsilateral cerebellum, bilateral SII, and SI.The activated brain regions (number of voxels) of the MI, SI, cerebellum, and SMA were largest during voluntary contraction alone and smallest during FES alone. SII-activated brain regions were largest during voluntary contraction combined with FES and smallest during FES contraction alone. The brain activation extent (maximum t score) of the MI, SI, and SII was largest during voluntary contraction alone and smallest during FES alone. The brain activation extent of the cerebellum and SMA during voluntary contraction alone was similar during FES combined with voluntary contraction; however, cerebellum and SMA activation during FES movement alone was smaller than that of voluntary contraction alone or voluntary contraction combined with FES. Between FES movement alone and combined contraction, activated regions and extent due to combined contraction was significantly higher than that of FES movement alone in the ipsilateral cerebellum and the contralateral MI and SI.ConclusionsVoluntary contraction combined with FES may be more effective for brain activation than FES-only movements for rehabilitation therapy. In addition, voluntary effort is the most important factor in the therapeutic process.

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A functional MRI study of somatotopic representation of somatosensory stimulation in the cerebellum

Cited by 31 publications

References 13 publications

Cortical and subcortical correlates of functional electrical stimulation of wrist extensor and flexor muscles revealed by fMRI

Cortical and subcortical correlates of functional electrical stimulation of wrist extensor and flexor muscles revealed by fMRI

Functional Topography of the Human Cerebellum Revealed by Functional Neuroimaging Studies

Evaluation of the brain activation induced by functional electrical stimulation and voluntary contraction using functional magnetic resonance imaging

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