A functional natural deep eutectic solvent based on trehalose: Structural and physicochemical properties

Xin, Ruipu; Qi, Suijian; Zeng, Chaoxi; Khan, Faez Iqbal; Yang, Bo; Wang, Yonghua

doi:10.1016/j.foodchem.2016.09.012

Cited by 110 publications

(76 citation statements)

References 27 publications

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“…23 The secondary structure of lysozyme in DES has been previously investigated by Esquembre et al and Xin et al using CD. 10,12 Our results were found to be in agreement with those previously published, showing a minimal change of the alpha helices and beta sheets in choline chloride:glycerol, and choline chloride:urea. 10 Lysozyme has also been studied using CD in a choline chloride:trehalose:water buffer, showing an increase in the thermostability of the protein.…”

supporting

confidence: 92%

“…4 DES have been demonstrated to promote amphiphile selfassembly of surfactants and phospholipids, both essential for the formation of biological membranes. [5][6][7][8][9] Protein stability has been investigated in various DES, [10][11][12][13] and enzymatic activity has been explored as an alternative to water for enzyme-catalysed reactions. [14][15][16] Bacterial preservation has also been demonstrated in DES.…”

mentioning

confidence: 99%

“…17 Unlike in organic solvents, where it has been shown that enzymatic activity is dramatically reduced, 18 DES and DES/water mixtures have been shown to partially preserve such activity. 12 The structure of proteins in these media has been previously studied by means of circular dichroism (CD). 10 Although such studies provide an insight on the secondary structure of proteins, information on the overall conformation of the proteins in solution is yet missing and not fully understood.…”

mentioning

confidence: 99%

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Protein conformation in pure and hydrated deep eutectic solvents

Sanchez-Fernandez

Edler

Arnold

et al. 2017

Phys. Chem. Chem. Phys.

108

114

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supporting

confidence: 92%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Protein conformation in pure and hydrated deep eutectic solvents

Sanchez-Fernandez

Edler

Arnold

et al. 2017

Phys. Chem. Chem. Phys.

108

114

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“…DESs show many advantageous properties, such as easy to produce, non‐flammable, non/low‐toxic, relatively high solubility, biocompatible and biodegradable . These properties enable DESs to be used in various fields, such as in pharmaceutics, synthesis of porous materials, electrochemistry and extraction processes . The most common DESs are based on choline chloride, which is an inexpensive and easily accessible compound.…”

Section: Introductionmentioning

confidence: 99%

Extraction of Alkaloids from Coptidis Rhizoma via Betaine‐Based Deep Eutectic Solvents

Hsieh

Pan

et al. 2020

ChemistrySelect

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To avoid the use of volatile organic compounds, a series of betaine-based deep eutectic solvents (DESs), which are considered as green solvents, were prepared for the efficient extraction of alkaloids from coptidis rhizome. The extraction conditions were optimized via response surface methodology (RSM) to achieve the maximum recovery of total alkaloids. A central composite design with three independent variables which included the concentration of the selected DES, extrac-tion time, and solvent/solid ratio at five levels, was applied while response surface plots were produced with a second order polynomial model. A one-off experiment was performed to examine the reliability of the simulated results obtained from RSM. An optimized yield of 128.43 mg/g was obtained at an extraction time of 29.5 min and a solvent/solid ratio of 35 : 1 with the extraction solvent as 0.6 M betaine-tartaric acid-water DES.

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“…In addition, Bajkacz and Adamek et al [37] also showed that NADES can be applied for isoflavone extraction. NADES can also be applied for protein stabilization [38], bioavailability improvement [39], antimicrobial agent [40] and bioactivity enhancement of plant extract [41]. Most of them used choline chloride-based NADES, the best combination of NADES which is suitable with their studied compounds.…”

Section: Extraction Of Phenolic and Alkaloid Compounds Using Natural mentioning

confidence: 99%

Green Separation of Bioactive Natural Products Using Liquefied Mixture of Solids

Zullaikah¹,

Rachmaniah²,

Utomo³

et al. 2018

Green Chemistry

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Bioactive natural products are secondary metabolites of plants and animals generated through various biological pathways. They are the main sources of new drugs, functional food and food additives. Since their contents in plant and animal tissues are extremely small compared to those of primary metabolites, the separations of bioactive principles from complex matrixes are often the inherent bottleneck in the utilization of bioactive natural products. A novel separation technique based on a liquefied mixture of solids at its eutectic compositions is presented in this chapter. The mixture can be prepared from natural primary metabolites and therefore can be considered as a green solvent. The separation of bioactive compounds (γ-oryzanol) from rice bran oil-based biodiesel using green methods with minimum energy requirement is discussed. Other applications for separations of alkaloid and phenolic compounds from their plant matrices are also presented. Different raw materials require different separation techniques due to the presence of different impurities, and the current trend is to use green methods with minimum energy requirement. This overview of recent technological advances, discussion of pertinent problems and prospect of current methodologies in the separation of bioactive natural products may provide a driving force for the development of novel separation techniques.

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A functional natural deep eutectic solvent based on trehalose: Structural and physicochemical properties

Cited by 110 publications

References 27 publications

Protein conformation in pure and hydrated deep eutectic solvents

Protein conformation in pure and hydrated deep eutectic solvents

Extraction of Alkaloids from Coptidis Rhizoma via Betaine‐Based Deep Eutectic Solvents

Green Separation of Bioactive Natural Products Using Liquefied Mixture of Solids

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