A functional perspective of nitazoxanide as a potential anticancer drug

Santo, Nicola Di; Ehrisman, Jessie

doi:10.1016/j.mrfmmm.2014.05.005

Cited by 50 publications

(52 citation statements)

References 75 publications

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“…Among normal tissues, niclosamide showed toxicity against human umbilical vein endothelial cells (HUVECs) and fibroblast-like synovioblasts [54]. Similar results were obtained when the toxicity of niclosamide and oxyclozanide were evaluated against HEK293 human embryonic kidney cells [35,36]. In relation to nonmalignant disease, the drug was used to treat an experimental fibrosis in mice [55].…”

Section: Anticancer Activity Of Niclosamidementioning

confidence: 56%

“…In combination with cisplatin, niclosamide inhibited epithelialmesenchymal transition (EMT) and tumor growth in triple-negative breast cancer [34]. The cytotoxicity of niclosamide and oxyclozanide were evaluated against HepG2 human liver carcinoma cells and both drugs caused a dose-dependent loss in cell viability [35,36]. Furthermore, niclosamide proved cytotoxic for glioblastoma and myelogeneous leukemia stem cells as well as NSCLC cells via NFκB and generation of reactive oxygen species (ROS) [37 -39].…”

Section: Anticancer Activity Of Niclosamidementioning

confidence: 99%

“…Signaling pathways Cancer cells [45], osteosarcoma [37], STAT3 CSCs [46], Wnt/β-catenin ovarian cancer [43], prostate cancer [36], NSCLC/ c-Jun-ROS [35], colorectal cancer/TNIK [30].…”

Section: Niclosamide Targetsmentioning

confidence: 99%

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Repurposing of Anthelminthics as Anticancer Drugs

Hamilton¹,

Rath²

2018

Oncomedicine

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Section: Anticancer Activity Of Niclosamidementioning

confidence: 56%

Section: Anticancer Activity Of Niclosamidementioning

confidence: 99%

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Repurposing of Anthelminthics as Anticancer Drugs

Hamilton¹,

Rath²

2018

Oncomedicine

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“…Nitazoxanide might simultaneously offer anti-inflammatory and pro-autophagic actions in mouse models with bacterial lipopolysaccharide-stimulated macrophages through blocking the production of IL6, which constitutes a barrier against various inflammatory processes including malignant transformation. 82,83 The role of other antimicrobial drugs in xenophagy and bacterial-associated cancer needs to be further investigated.…”

Section: The Role Of Xenophagy In Bacterial-associated Cancermentioning

confidence: 99%

Bacterial xenophagy and its possible role in cancer: A potential antimicrobial strategy for cancer prevention and treatment

et al. 2016

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Macroautophagy/autophagy is a conserved catabolic process through which cellular excessive or dysfunctional proteins and organelles are transported to the lysosome for terminal degradation and recycling. Over the past few years increasing evidence has suggested that autophagy is not only a simple metabolite recycling mechanism, but also plays a critical role in the removal of intracellular pathogens such as bacteria and viruses. When autophagy engulfs intracellular pathogens, the pathway is called 'xenophagy' because it leads to the elimination of foreign microbes. Recent studies support the idea that xenophagy can be modulated by bacterial infection. Meanwhile, convincing evidence indicates that xenophagy may be involved in malignant transformation and cancer therapy. Xenophagy can suppress tumorigenesis, particularly during the early stages of tumor initiation. However, in established tumors, xenophagy may also function as a prosurvival pathway in response to microenvironment stresses including bacterial infection. Therefore, bacterial infection-related xenophagy may have an effect on tumor initiation and cancer treatment. However, the role and machinery of bacterial infection-related xenophagy in cancer remain elusive. Here we will discuss recent developments in our understanding of xenophagic mechanisms targeting bacteria, and how they contribute to tumor initiation and anticancer therapy. A better understanding of the role of xenophagy in bacterial infection and cancer will hopefully provide insight into the design of novel and effective therapies for cancer prevention and treatment.

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“…Nitazoxanide is also an alternative therapy for Clostridium difficile diarrhea in inpatients [2-6]. In addition to the above uses, recent studies have found a promising anticancer effect of nitazoxanide, which could have a major impact on public health [7-8]. …”

Section: Introductionmentioning

confidence: 99%

Bibliometric Assessment of the Global Scientific Production of Nitazoxanide

Rodríguez‐Morales

Martínez-Pulgarín

Muñoz

et al. 2017

Cureus

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IntroductionNitazoxanide is a member of a new class of drug, thiazolides, and it was discovered in 1984 with antimicrobial activity effect against anaerobic bacteria, Hepatitis virus, protozoa, and helminths.MethodsA bibliometric study on four databases (1984-2016) – Medline, Scopus, LILACS, and SciELO – characterizing the global scientific production of nitazoxanide. We determined the quantity, quality (number of citations), and types of studies developed by each country, characterizing them by years, international cooperation, development, place of publication, authors (with its H-index), and groups with higher impact.ResultsThere were 512 articles in Medline – the higher scientific production is from the USA (19.71%), Switzerland (7.51%), and Mexico (7.27%). There were 1,440 articles in Scopus – from the USA (8.98%), Mexico (2.13%), and India (1.65%). There were 405 articles in LILACS – from Mexico (4.69%), the USA (4.2%), and Peru (2.47%). There were 47 articles in SciELO – from Brazil (34.04%), Venezuela (21.28%), and Colombia (14.89%). The H-index of nitazoxanide is 75 – the USA (26), Egypt (12), and Canada (10) were the countries contributing more with that.ConclusionsNitazoxanide research has been highly important. Nevertheless, it is relatively limited when compared with other drugs. Its research has been led by the USA, as revealed in this bibliometric assessment. Although some developing countries, where it is used especially for protozoa and helminths, probably have its influence, and this explains the fact that Mexico and India, among others, are the top countries in the scientific production of this anti-infective agent. This bibliometric study evidenced a relatively low number of publications, however, it has been increased in recent years.

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A functional perspective of nitazoxanide as a potential anticancer drug

Cited by 50 publications

References 75 publications

Repurposing of Anthelminthics as Anticancer Drugs

Repurposing of Anthelminthics as Anticancer Drugs

Bacterial xenophagy and its possible role in cancer: A potential antimicrobial strategy for cancer prevention and treatment

Bibliometric Assessment of the Global Scientific Production of Nitazoxanide

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