2000
DOI: 10.1128/mmbr.64.2.354-411.2000
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A Functional-Phylogenetic Classification System for Transmembrane Solute Transporters

Abstract: SUMMARY A comprehensive classification system for transmembrane molecular transporters has been developed and recently approved by the transport panel of the nomenclature committee of the International Union of Biochemistry and Molecular Biology. This system is based on (i) transporter class and subclass (mode of transport and energy coupling mechanism), (ii) protein phylogenetic family and subfamily, and (iii) substrate specificity. Almost all of the more than 250 identified families of tran… Show more

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Cited by 747 publications
(652 citation statements)
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References 152 publications
(157 reference statements)
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“…Orthologous genes were analyzed using bidirectional BLAST 47 best hit (E-value threshold of 10 À10 ). Solute transporters were classified using the TC number system 48 .…”
Section: Methodsmentioning
confidence: 99%
“…Orthologous genes were analyzed using bidirectional BLAST 47 best hit (E-value threshold of 10 À10 ). Solute transporters were classified using the TC number system 48 .…”
Section: Methodsmentioning
confidence: 99%
“…TCDB is widely used, averaging over 50 different users per day from research institutions all over the world. TCDB defines and implements the transport classification system [10] for categorizing transport proteins, which was adopted by the International Union of Biochemistry and Molecular Biology as the international standard in 2002.…”
Section: Introductionmentioning
confidence: 99%
“…Primary and secondary transporters facilitate solute transport into the cell coupled with a source of energy (i.e., a chemical reaction, light absorption, or electron flow) or an ion electrochemical gradient, respectively (28). Third, group translocators modify their substrates during transport such as phosphorylation.…”
mentioning
confidence: 99%
“…Transport of 4-chlorobenzoate shows significant inhibition by 4-bromo-, 4-iodo-, and 4-fluorobenzoate and mild inhibition by 3-chlorobenzoate, 2-chlorobenzoate, 4-hydroxybenzoate, 3-hydroxybenzoate, and benzoate. Uptake of 4-chlorobenzoate is significantly inhibited by ionophores which collapse the proton motive force.Bacterial transport systems have traditionally been divided into four general classes based on energy coupling mechanisms, primary sequence, and mode of transport (7,16,25,28). Primary and secondary transporters facilitate solute transport into the cell coupled with a source of energy (i.e., a chemical reaction, light absorption, or electron flow) or an ion electrochemical gradient, respectively (28).…”
mentioning
confidence: 99%
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