A functional polymorphism in the promoter region of interleukin-10 gene increases the risk for spontaneous abortions—a triad study

Vidyadhari, M.; Sujatha, M.; Krupa, Paul L.; Jyothy, A.; Nallari, Pratibha; Ananthapur, Venkateshwari

doi:10.1007/s10815-015-0504-4

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…37 The studies analyzed identified changes in pro-inflammatory cytokines such as IL-1β, IL-18 13,16,17,38,39 and IL-10, which can have an anti-inflammatory or pro-inflammatory effect. 37,40 Another contribution of the immune system in spontaneous abortion is referred to as a response, in which Human Leukocyte Antigens (HLA) stimulate the maternal immune system against the presence of the fetus. 41 Regarding genetic changes, the polymorphisms of the vascular endothelial growth factor -VEGF stand out (this being an important factor in the regulation of fetal and placental angiogenesis), 8,42 VEGF 43 receptor polymorphism and growth factor polymorphism similar to insulin-2 -IGF-2 (main fetal-placental growth factor that stimulates trophoblast invasion and growth).…”

Section: Discussionmentioning

confidence: 99%

Factors associated with spontaneous abortion: a systematic review

Oliveira

Marques

et al. 2020

Rev. Bras. Saude Mater. Infant.

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Objectives: to compile studies produced regardinggenetic and non-genetic risks factors associated with occurrence of spontaneous abortion. Methods: it talks about a systematic review article, with studies between January of 2008 to November of 2018 according to SciELO, PubMed, Lilacs and BVS. Results: in total, 567 articles were found. After applying the definedeligibility criteria, 44 articles made part of the review, being the majority published on Asia between 2008 and 2011, and 10 articles published on Brazil. Not genetic causes like sociodemographic factors and healthy state were among the most associated conditions of spontaneous abortion. Asiatic continent had predominance about the correlation of spontaneous abortion with factors related to life style like obesity, smoking and labor activities, on the other hand, in the Americas, causes related to sociodemographics factors like low pay and low studies are high-lighted. Conclusions: the risk factors change about the occurrence region, being important to make local studies capable of subsidize the implantation of public politics and to reduce abortions.

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Section: Discussionmentioning

confidence: 99%

Factors associated with spontaneous abortion: a systematic review

Oliveira

Marques

et al. 2020

Rev. Bras. Saude Mater. Infant.

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“…The −1082A/G (rs1800896) polymorphism of the IL-10 gene's promoter region has been extensively studied due to its reported involvement in the abnormal expression of IL-10 in RM. [ 21 61 63 64 65 66 67 68 ] It has also been revealed by a study conducted on a hypertensive rat model that IL-10 contributes to the normalisation of blood pressure and endothelial function. These results highlight the significance of this cytokine in a healthy pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…[ 58 ] In addition, our results were also supported by the findings of several studies. [ 64 65 66 ] A meta-analysis by Peng et al . found a significant association between −1082A/G polymorphism and RM risk, and they also concluded that G allele, as well as the GG genotype, increased the risk.…”

Section: Discussionmentioning

confidence: 99%

Impact of Interleukin-10 Promoter Region Polymorphisms on Recurrent Miscarriage: A Case–Control Approach

Kaur

Sudhir

Kaur

et al. 2023

Journal of Human Reproductive Sciences

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A BSTRACT Background: Recurrent miscarriage (RM), defined as two or more consecutive miscarriages prior to the 20 th week of gestation is characterised by multifactorial aetiology. The prevalence of RM varies from 0.8% to 13.5% amongst women of reproductive age. The aetiological basis of RM has been traced to chromosomal, anatomic, hormonal and immunologic factors while half of the cases remain idiopathic. Aims: This study aimed to investigate the association of interleukin-10 (IL-10) polymorphisms with RM amongst the Indian population. Settings and Design: The present study included a total of 414 individuals including RM women ( n = 199) with two or more pregnancy losses and healthy women ( n = 215) without any previous history of pregnancy loss were taken as the control group. Materials and Methods: Demographic features and reproductive history of women with RM and healthy women were taken. Genotype analysis of IL-10 polymorphisms rs1800872 and rs1800896 was performed using the polymerase chain reaction (PCR) restriction fragment length polymorphism and amplification mutation refractory system PCR, respectively. Statistical Analysis Used: Student's t -test was used to compare the demographic features and reproductive history amongst both groups. Pearson's Chi-square was used to calculate the Hardy–Weinberg equilibrium, allelic and genotypic frequencies. All the statistical analyses were performed using the SPSS (version 21, IBM SPSS, NY, USA). Results: Our results suggested that the genotypic and allelic frequency of rs1800872 polymorphism did not differ significantly between RM cases and control women ( P = 0.07 and P = 0.23, respectively). The GG genotype ( P = 0.007) and G allele ( P = 0.003) of rs1800896 were significantly associated with an increased risk of RM. A statistically significant difference was also found for the distribution of genetic models (dominant and co-dominant model) between both groups for rs1800896. However, haplotype analysis revealed that none of the haplotypes provides a risk for the progression of RM. Conclusion: The study is the first of its kind from our region and provides baseline data on the genetics of RM.

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