A functional variant in the coding region of CAMTA2 is associated with left ventricular hypertrophy by affecting the activation of Nkx2.5-dependent transcription

Song, Weihua; Lin, Ya-Hui; Sun, Kai; Zhang, Yinhui; Song, Yan; Hou, Li-Bo; Zhang, Channa; Hui, Rutai; Chen, Jingzhou

doi:10.1097/hjh.0000000000000873

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…It was speculated that CAMTA homeotic genes in eggplant were involved in the growth and development of tissues and organs. Research in Arabidopsis showed that AtCAMTA2 is an activated transcription factor of AtALMT1 (aluminum activated malic acid transporter 1) [48], and AtCAMTA3 plays a negative regulation role in SA-mediated plant defense response [30,49]. The loss of repression of AtCAMTA1, AtCAMTA2, and AtCAMTA3 can induce the initiation of plant defense genes and systemic resistance [23].…”

Section: Discussionmentioning

confidence: 99%

Identification and Molecular Characterization of the CAMTA Gene Family in Solanaceae with a Focus on the Expression Analysis of Eggplant Genes under Cold Stress

Cai,

Lan,

Gong

et al. 2024

IJMS

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Calmodulin-binding transcription activator (CAMTA) is an important calmodulin-binding protein with a conserved structure in eukaryotes which is widely involved in plant stress response, growth and development, hormone signal transduction, and other biological processes. Although CAMTA genes have been identified and characterized in many plant species, a systematic and comprehensive analysis of CAMTA genes in the Solanaceae genome is performed for the first time in this study. A total of 28 CAMTA genes were identified using bioinformatics tools, and the biochemical/physicochemical properties of these proteins were investigated. CAMTA genes were categorized into three major groups according to phylogenetic analysis. Tissue-expression profiles indicated divergent spatiotemporal expression patterns of SmCAMTAs. Furthermore, transcriptome analysis of SmCAMTA genes showed that exposure to cold induced differential expression of many eggplant CAMTA genes. Yeast two-hybrid and bimolecular fluorescent complementary assays suggested an interaction between SmCAMTA2 and SmERF1, promoting the transcription of the cold key factor SmCBF2, which may be an important mechanism for plant cold resistance. In summary, our results provide essential information for further functional research on Solanaceae family genes, and possibly other plant families, in the determination of the development of plants.

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Section: Discussionmentioning

confidence: 99%

Identification and Molecular Characterization of the CAMTA Gene Family in Solanaceae with a Focus on the Expression Analysis of Eggplant Genes under Cold Stress

Cai,

Lan,

Gong

et al. 2024

IJMS

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“…No research on ENST00000575985.1 was conducted yet. However, several studies have reported the role of CAMTA2 in cardiovascular diseases 27,28 . ENST00000556899.1, which is also named as CTD‐2536I1.1‐001 (Ensembl Human GRCh37.…”

Section: Discussionmentioning

confidence: 99%

Circulating exosomal long non‐coding RNAs in patients with acute myocardial infarction

Zheng

Liu

Han

et al. 2020

J Cellular Molecular Medi

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Exosomes are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized in acute myocardial infarction (AMI). However, the regulatory role of exosomal long non‐coding RNAs (lncRNAs) in AMI remains largely unclear. Exosomes were isolated from the plasma of AMI patients and controls, and the sequencing profiles and twice qRT‐PCR validations of exosomal lncRNAs were performed. A total of 518 differentially expressed lncRNAs were detected over two‐fold change, and 6 kinds of lncRNAs were strikingly elevated in AMI patients with top fold change and were selected to perform subsequent validation. In the two validations, lncRNAs ENST00000556899.1 and ENST00000575985.1 were significantly up‐regulated in AMI patients compared with controls. ROC curve analysis revealed that circulating exosomal lncRNAs ENST00000556899.1 and ENST00000575985.1 yielded the area under the curve values of 0.661 and 0.751 for AMI, respectively. Moreover, ENST00000575985.1 showed more significant relationship with clinical parameters, including inflammatory biomarkers, prognostic indicators and myocardial damage markers. Multivariate logistic model exhibited positive association of ENST00000575985.1 with the risk of heart failure in AMI patients. In summary, our data demonstrated that circulating exosomal lncRNAs ENST00000556899.1 and ENST00000575985.1 are elevated in patients with AMI, functioning as potential biomarkers for predicting the prognosis of pateints with AMI.

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“…3 It has been reported that CAMTA2 as a novel coactivator of Nkx2.5 and required for a maximal cardiac growth response. 4,5 Array-based comparative genomic study -----------------------------------------------------------------------------------------------demonstrates that CAMTA2 is downregulated in pancreatic cancer tissues. 6 The function of CAMTA2 in colon cancer development has not been reported.…”

Section: Introductionmentioning

confidence: 99%

“…Calmodulin‐binding transcription activator 2 (CAMTA2) belongs to the calmodulin‐binding transcription activator family 3. It has been reported that CAMTA2 as a novel coactivator of Nkx2.5 and required for a maximal cardiac growth response 4,5. Array‐based comparative genomic study demonstrates that CAMTA2 is downregulated in pancreatic cancer tissues 6.…”

Section: Introductionmentioning

confidence: 99%

The miR‐28‐5p‐CAMTA2 axis regulates colon cancer progression via Wnt/β‐catenin signaling

Luan

Wang

Gai

2019

J of Cellular Biochemistry

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Background Colon cancer is the third most commonly diagnosed cancer with high morbidity and mortality. Calmodulin‐binding transcription activator 2 (CAMTA2) belongs to the calmodulin‐binding transcription activator protein family. The functional role of CAMTA2 in colon cancer development remains unclear. Our research found out that CAMTA2 was high‐level expressed in colon cancer, and the upregulated CAMTA2 expression was markedly correlated with poor survival. Functional experiments showed that knockdown of CAMTA2 repressed colon cancer cell proliferation/migration in vitro and attenuated proliferation in vivo. In additional, CAMTA2 expression was controlled by miR‐28‐5p via posttranscriptional regulation and miR‐28‐5p expression was reversely correlated with CAMTA2 expression in colon cancer. Moreover, enforced miR‐28‐5p expression downregulated the expression of CAMTA2 significantly and the restoration of CAMTA2 expression abolished the inhibitory effect of miR‐28‐5p on colon cancer cell proliferation and metastasis. Mechanistically, overexpression of miR‐28‐5p suppressed Wnt/β‐catenin signaling and the inhibitory could be partly abolished by overexpression of CAMTA2. In summary, our findings reveal that miR‐28‐5p/CAMTA2 axis plays a critical role in human colon cancer, which might be a promising diagnosis and therapeutic target for colon cancer treatment.

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A functional variant in the coding region of CAMTA2 is associated with left ventricular hypertrophy by affecting the activation of Nkx2.5-dependent transcription

Abstract: Our results provide evidence that the rs238234 GG genotype in the coding region of CAMTA2 may increase the risk of LVH by affecting the activation of Nkx2.5-dependent transcription.

Cited by 7 publications

References 29 publications

Identification and Molecular Characterization of the CAMTA Gene Family in Solanaceae with a Focus on the Expression Analysis of Eggplant Genes under Cold Stress

Identification and Molecular Characterization of the CAMTA Gene Family in Solanaceae with a Focus on the Expression Analysis of Eggplant Genes under Cold Stress

Circulating exosomal long non‐coding RNAs in patients with acute myocardial infarction

The miR‐28‐5p‐CAMTA2 axis regulates colon cancer progression via Wnt/β‐catenin signaling

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