“…On the other hand, the use of pulses has several physiological benefits (in fact, the healthy pancreas segregates insulin in such a way, every 5-10 min, [28,29]). Studies have shown both, experimentally [6,5,30] and theoretically [31,32], that a better postprandial control is achieved by shot boluses, especially in the case of meals with high glycemic index (HGI). Moreover, a pulsatile insulin delivery suppresses more effectively the hepatic glucose release, as stated in [29,33].…”