To meet the needs of underground anti-seepage projects such as landfills better, the anti-seepage slurry modified by sodium carboxymethyl cellulose (CMC-Na) was prepared through laboratory experiments on the basis of the preliminary study of PBFC anti-seepage slurry. The main material of the slurry is bentonite modified by sodium carboxymethyl cellulose, cement, fly ash and auxiliary materials such as sodium carbonate and polycarboxylate superplasticizer. The optimal ratio of the basic components of the anti-seepage slurry was optimized by the orthogonal test method. The permeability coefficient of the slurry was tested by the self-made constant head permeameter, and the age-resistant compressive strength was tested by the electronic press. The optimal mass ratio of each component of 1 liter slurry is: 20–22% bentonite, 20–22% cement, 16% fly ash, 0.15–0.2% sodium carbonate, 0.15–0.2% sodium carboxymethyl cellulose, 0.3% polycarboxylate superplasticizer. The permeability coefficient of the slurry consolidation body for 28 days is less than [Formula: see text]cm/s, and the unconfined compressive strength is 0.5–2.0 MPa. The performance indexes of the slurry are higher than those of the existing anti-seepage slurry, which can better meet the anti-seepage standard of urban landfill in China.