Abstract. We develop Weyl-Titchmarsh theory for self-adjoint Schrödinger operators H α in L 2 ((a,b);dx;H ) associated with the operator-valued differential expression, and H a complex, separable Hilbert space. We assume regularity of the left endpoint a and the limit point case at the right endpoint b . In addition, the bounded self-adjoint operator α = α * ∈ B(H ) is used to parametrize the self-adjoint boundary condition at the left endpoint a of the typewith u lying in the domain of the underlying maximal operator H max in L 2 ((a,b);dx;H ) associated with τ . More precisely, we establish the existence of the Weyl-Titchmarsh solution of H α , the corresponding Weyl-Titchmarsh m -function m α and its Herglotz property, and determine the structure of the Green's function of H α .Developing Weyl-Titchmarsh theory requires control over certain (operator-valued) solutions of appropriate initial value problems. Thus, we consider existence and uniqueness of solutions of 2nd-order differential equations with the operator coefficient V ,, and f ∈ L 1 loc ((a,b);dx;H ) . We also study the analog of this initial value problem with y and f replaced by operator-valued functions Y,F ∈ B(H ) .Our hypotheses on the local behavior of V appear to be the most general ones to date. Mathematics subject classification (2010): Primary: 34A12, 34B20, 34B24; Secondary: 47E05.