In this article, we study minimal isometric immersions of Kähler manifolds into product of two real space forms. We analyse the obstruction conditions to the existence of pluriharmonic isometric immersions of a Kähler manifold into those spaces and we prove that the only ones into
𝕊
m
-
1
×
ℝ
{\mathbb{S}^{m-1}\times\mathbb{R}}
and
ℍ
m
-
1
×
ℝ
{\mathbb{H}^{m-1}\times\mathbb{R}}
are the minimal isometric immersions of Riemannian surfaces. Furthermore, we show that the existence of a minimal isometric immersion of a Kähler manifold
M
2
n
{M^{2n}}
into
𝕊
m
-
1
×
ℝ
{\mathbb{S}^{m-1}\times\mathbb{R}}
and
𝕊
m
-
k
×
ℍ
k
{\mathbb{S}^{m-k}\times\mathbb{H}^{k}}
imposes strong restrictions on the Ricci and scalar curvatures of
M
2
n
{M^{2n}}
. In this direction, we characterise some cases as either isometric immersions with parallel second fundamental form or anti-pluriharmonic isometric immersions.