A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action

Haywood, Joel; Breese, Karen J.; Zhang, Jingjing; Waters, Mark T.; Bond, Charles S.; Stubbs, Keith A.; Mylne, Joshua S.

doi:10.1038/s41467-022-33185-0

Cited by 11 publications

(5 citation statements)

References 79 publications

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“…The source of information for virtual screening commonly includes chemical structures from published materials or available databases and any commercial or original libraries of synthetic and/or natural compounds. As a rule, specialized sets of drug-like substances are used [ 11 ] since some of them possess phytotoxic properties, for example, sulfonamide antibiotics [ 12 ], salicylic acid [ 13 ], hypotensive [ 14 ], and antimalarial substances [ 15 ], as well as statins [ 16 ]. There are also specialized commercial libraries of herbicide-like compounds [ 17 , 18 ].…”

Section: Current Trends In Herbicide Developmentmentioning

confidence: 99%

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Berestetskiy

2023

Plants

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Weeds are a permanent component of anthropogenic ecosystems. They require strict control to avoid the accumulation of their long-lasting seeds in the soil. With high crop infestation, many elements of crop production technologies (fertilization, productive varieties, growth stimulators, etc.) turn out to be practically meaningless due to high yield losses. Intensive use of chemical herbicides (CHs) has led to undesirable consequences: contamination of soil and wastewater, accumulation of their residues in the crop, and the emergence of CH-resistant populations of weeds. In this regard, the development of environmentally friendly CHs with new mechanisms of action is relevant. The natural phytotoxins of plant or microbial origin may be explored directly in herbicidal formulations (biorational CHs) or indirectly as scaffolds for nature-derived CHs. This review considers (1) the main current trends in the development of CHs that may be important for the enhancement of biorational herbicides; (2) the advances in the development and practical application of natural compounds for weed control; (3) the use of phytotoxins as prototypes of synthetic herbicides. Some modern approaches, such as computational methods of virtual screening and design of herbicidal molecules, development of modern formulations, and determination of molecular targets, are stressed as crucial to make the exploration of natural compounds more effective.

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Section: Current Trends In Herbicide Developmentmentioning

confidence: 99%

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Berestetskiy

2023

Plants

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“…The source of information for virtual screening commonly includes chemical structures from published materials or available databases, any commercial or original libraries of synthetic and/or natural compounds. As a rule, specialized sets of drug-like substances are used [11], since some of them possess phytotoxic properties, for example: sulfonamide antibiotics [12], salicylic acid [13], hypotensive [14] and antimalarial substances [15], as well as statins [16]. There are also specialized commercial libraries of herbicide-like compounds [17,18].…”

Section: Screeningmentioning

confidence: 99%

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Berestetskiy¹

2022

Preprint

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Weeds are a permanent component of anthropogenic ecosystems, which requires strict control to avoid the accumulation of their long–lasting seeds in the soil. With high crop infestation, many elements of crop production technologies (fertilization, productive varieties, growth stimulators, etc.) turn out to be practically meaningless due to high yield losses. Intensive use of chemical herbicides (CH) has led to undesirable consequences: contamination of soil and wastewater, accumulation of their residues in the crop, the emergence of CH-resistant populations of weeds. In this regard, the development of environmentally friendly CH with new mechanisms of action is relevant. Natural phytotoxins of plant or microbial origin may be directly explored in herbicidal formulations (biorational CH) or indirectly as scaffolds for nature-derived CH. This review considers: 1) the main current trends in the development of CH that may be important for enhancement of biorational herbicides; 2) advances in the development and practical application of natural compounds for weed control; 3) the use of phytotoxins as prototypes of synthetic herbicides. Some modern approaches such as computational methods of virtual screening and design herbicidal molecules, development of modern formulations, determination of molecular targets are stressed as important to make exploration of natural compounds more effective.

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“…3 However, with increasing awareness of the importance of environmental protection and sustainable development, as well as the constant emergence of resistant weeds, innovative varieties of herbicides are needed to meet production and market demands. 4,5 The discovery of new herbicide targets and lead structures with herbicidal activity provides a promising foundation for herbicide development. 6 To date, over 20 specific protein targets have been identified for approved herbicides, 7 encompassing processes such as photosynthesis, cellular metabolism, cell division, and growth.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Weeds compete with crops for resources such as nutrients, water, space, and sunlight, severely affecting crop production. , Chemical herbicides have become essential agricultural production materials because of their excellent performance in managing weeds and reducing labor costs . However, with increasing awareness of the importance of environmental protection and sustainable development, as well as the constant emergence of resistant weeds, innovative varieties of herbicides are needed to meet production and market demands. , …”

Section: Introductionmentioning

confidence: 99%

Discovery of Novel Pyrazole Acyl Thiourea Skeleton Analogue as Potential Herbicide Candidates

Ma,

Tian,

Wang

et al. 2024

J. Agric. Food Chem.

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To discover novel transketolase (TKL, EC 2.2.1.1) inhibitors with potential herbicidal applications, a series of pyrazole acyl thiourea derivatives were designed based on a previously obtained pyrazolamide acyl lead compound, employing a scaffold hopping strategy. The compounds were synthesized, their structures were characterized, and they were evaluated for herbicidal activities. The results indicate that 7a exhibited exceptional herbicidal activity against Digitaria sanguinalis and Amaranthus retroflexus at a dosage of 90 g ai/ha, using the foliar spray method in a greenhouse. This performance is comparable to that of commercial products, such as nicosulfuron and mesotrione. Moreover, 7a showed moderate growth inhibitory activity against the young root and stem of A. retroflexus at 200 mg/L in the small cup method, similar to that of nicosulfuron and mesotrione. Subsequent mode-of-action verification experiments revealed that 7a and 7e inhibited Setaria viridis TKL (SvTKL) enzyme activity, with IC 50 values of 0.740 and 0.474 mg/L, respectively. Furthermore, they exhibited inhibitory effects on the Brassica napus acetohydroxyacid synthase enzyme activity. Molecular docking predicted potential interactions between these (7a and 7e) and SvTKL. A greenhouse experiment demonstrated that 7a exhibited favorable crop safety at 150 g ai/ha. Therefore, 7a is a promising herbicidal candidate that is worthy of further development.

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A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action

Cited by 11 publications

References 79 publications

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Modern Approaches for the Development of New Herbicides Based on Natural Compounds

Discovery of Novel Pyrazole Acyl Thiourea Skeleton Analogue as Potential Herbicide Candidates

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