A further case of plantar squamous cell carcinoma arising in Olmsted syndrome

Yoshizaki, Yohei; Kanki, Hiroshi; Ueda, Tomohiro; Ichihashi, Masamitsu; Ueda, Masato

doi:10.1046/j.1365-2133.2001.04453.x

Cited by 32 publications

(30 citation statements)

References 10 publications

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“…Topical therapy with retinoic acid, corticosteroids, emollients, and keratolytics may offer temporary symptomatic relief. Although some authors reported good results with surgery, 10,14,26 full-thickness excision and skin grafting is unreliable because hyperkeratosis may recur at the grafted site and may develop at the donor site as a result of a Koebner phenomenon. Methotrexate 25 and systemic corticosteroids 8,15,19 do not control the lesions.…”

Section: Discussionmentioning

confidence: 96%

“…29 Olmsted's case described by Poulin et al 6 eventually developed four epithelioma cuniculatas (a low-grade squamous cell carcinoma) before age 40. 25 Other authors recently reported squamous cell carcinomas 23,26 and verrucous carcinomas 22 in keratoderma lesions. Many factors may contribute to the development of neoplasia in Olmsted syndrome: local hyperkeratosis with associated trauma, recurrent infections, and chronic use of local or systemic immunosuppressive agents.…”

Section: Discussionmentioning

confidence: 97%

“…It is already the treatment of choice for a number of palmoplantar keratodermas, and seven authors reported good results in Olmsted syndrome patients. 12,13,16,[18][19][20]26 Etretinate induces cellular differentiation, is antiproliferative and antiinflammatory, normalizes keratinization, and has inhibitory activity on neutrophil chemotaxis. 31 Our patient showed major improvement of the palmoplantar and genital lesions during etretinate therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Nonmelanocytic cutaneous neoplasia has already been described in association with Olmsted syndrome. 22,23,25,26 We present a new case of Olmsted syndrome highlighting two major points: definite improvement with systemic retinoids and association with malignant melanoma.…”

Section: Sommairementioning

confidence: 96%

See 3 more Smart Citations

Olmsted Syndrome?Palmoplantar and Periorificial Keratodermas: Association with Malignant Melanoma

Dessureault

Poulin

Bourcier

et al. 2003

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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An association between malignant epithelial tumors and Olmsted syndrome has already been reported. The association of malignant melanoma with other types of palmoplantar keratodermas has been reported. This may suggest a predisposition to melanocytic as well as squamous cell malignancies in congenital keratodermas. Oral retinoids appear to be the most promising treatment for Olmsted syndrome and for other symptomatic keratodermas.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Sommairementioning

confidence: 96%

See 2 more Smart Citations

Olmsted Syndrome?Palmoplantar and Periorificial Keratodermas: Association with Malignant Melanoma

Dessureault

Poulin

Bourcier

et al. 2003

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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“…In fact, no reports have described the association of PLS with nonmelanoma skin carcinomas, such as squamous cell carcinoma, developing within the hyperkeratotic skin. In contrast, other types of PPK, such as Olmsted syndrome [25] and Huriez syndrome [26, 27], are reportedly associated with squamous cell carcinoma. In this context, mal de Meleda might also possess this preferential tendency of melanoma development; so far, no association of nonmelanoma skin cancers has been reported for this disease.…”

Section: Discussionmentioning

confidence: 99%

Papillon-Lefèvre Syndrome and Malignant Melanoma

et al. 2008

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Papillon-Lefèvre syndrome (PLS) is a rare autosomal-recessive genodermatosis characterized by palmoplantar hyperkeratosis and severe early-onset periodontitis. The development of malignant cutaneous neoplasms within the hyperkeratotic lesions of the syndrome is quite rare. Here, we report on a 51-year-old Japanese woman with PLS associated with recurrent malignant melanoma (MM). Mutation analysis of the cathepsin C gene revealed that the proband was homozygous for a missense mutation, c.415G→A, which is predicted to result in the amino acid substitution p.G139R. Including our case, 4 families have been described as having PLS with MM, 3 of which are Japanese, implying a high incidence of melanoma development in Japanese PLS patients. We suggest that hereditary palmoplantar keratoderma (PPK) in Japanese patients might be predisposed to MM. A literature review revealed that in 18 cases of MM-associated PPK, 13 (76%) were Japanese, suggesting a high incidence of MM in Japanese PPK patients. This tendency might be attributable to the high frequency of acral lentiginous melanoma in Japanese subjects, in contrast to a lower frequency of this subtype in Caucasians.

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Inherited Disorders of Cornification

Oji

Metze

Traupe

2016

Rook's Textbook of Dermatology, Ninth Edition

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The majority of keratinization disorders are referred to as Mendelian disorders of cornification. This is a very broad group, clinically characterized by hyperkeratosis or visible scaling or both. This chapter deals with the ichthyoses, palmoplantar keratodermas (PPKs) and miscellaneous cornification disorders such as porokeratoses. It is aimed primarily at dermatologists and physician scientists who have to make a clinical diagnosis and provide adequate management for their patients. Therefore a nosology and classification scheme has been chosen that is based on clinicogenetic and morphological features. Clinical diagnoses are then discussed with their molecular pathology. Part of the chapter addresses the management of congenital ichthyoses. Various tables provide an overview on clinical and/or pathophysiologically related groups of diseases. Finally, several cornification disorders are discussed that do not have a genetic basis, but are acquired or are of unknown aetiology (e.g. acquired ichthyoses/PPKs or perforating keratotic disorders).

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A further case of plantar squamous cell carcinoma arising in Olmsted syndrome

Cited by 32 publications

References 10 publications

Olmsted Syndrome?Palmoplantar and Periorificial Keratodermas: Association with Malignant Melanoma

Olmsted Syndrome?Palmoplantar and Periorificial Keratodermas: Association with Malignant Melanoma

Papillon-Lefèvre Syndrome and Malignant Melanoma

Inherited Disorders of Cornification

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