A Further Contribution to the Histopathology of Paraffin Prosthesis.

Abstract

My paper contained much censure. I wish, therefore, to say that the work of the Council on Pharmacy and Chemistry, which is publishing its deliberations weekly in The Journal, is one of the best means that has been put forward thus far in order to cure the evils I have mentioned. One man may lead a horse to water, but 20,000 can not make him drink. If pharmacopeias are revised every five or ten years, or oftener, the very people who should read them will not. What can we do with them? The American Medical Association can wield a great influence; there are 32,000 members now, I am told. They will finally overcome these miserable trade journals, some of which since they became rich have become good. Let's keep up a constant warfare. It means a campaign of education, and I trust we shall keep at it until the body politic of medicine, which is now like an evil sore, is cleansed.

Ointment Granulomas Following Sutureless Transconjunctival Blepharoplasty

“…20 Ophthalmic ointments that include white petrolatum, paraffin, and mineral oil can stimulate a foreign body granulomatous reaction when exposed to subconjunctival blood vessels. 6,10,20,21 Heidingsfeld 21 in 1906 first described a foreign body reaction to lipid substances introduced for cosmetic and prosthetic procedures. Similar granulomas have resulted from ointments in nasal packing after sinonasal surgery.…”

Penile paraffinoma

“…In 1906, Heidingsfeld first described tumours of the penis resulting from paraffin injections. Quérnu and Pérol (1947) summarized six cases of paraffinoma using Vaseline where five of the six cases developed penile cancer and therefore histological analysis is indicated.…”

Periocular Petrolatum

“…3 Eventually, marked fibrosis develops with characteristic multiple polymorphic lipid dropout spaces, frequently described as a "Swiss cheeselike" pattern. 1,3,[11][12][13]19 Occasionally these lesions may be clinically mistaken for malignancy 10,15 and lymphangioma. Ultrastructurally, these lesions appear as isolated or coalescing vacuoles inside macrophages and fibroblasts.…”