A further evaluation of the new immunochemical fecal occult blood test Flexsure® OBT

Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry for the detection of hemoglobins as the protein biomarkers for fecal occult blood

“…Although a chemical method is the most widely used FOB diagnostic method nowadays, such an approach still suffers from its labor‐cost (or non‐automatic capability) and unreliability due to certain interference in subjects who are on unrestricted diets. Interference resulting from certain medicinal drugs with peroxidase‐active components such as iodine, boric acid, aspirin, non‐steroidal anti‐inflammatory steroids, anticoagulants, and large doses of iron preparations often results in crucial false‐positive diagnoses by guaiac‐based FOB tests 11–13. Certain foods containing high levels of heme/Hb (e.g., rice cakes mixed with mammal/poultry blood or red meat) may also cause false‐positive results 14.…”