A Further Example of Anti-Co^a and two Informative Families with Co(a-) Members

Anti Colton-A Foeto-Neonatal Haemolytic Disesase: Diagnosis; Clinical Outcome and Family Study

“…Product of this gene is a transmembrane water channel protein, aquaporin-1 (AQP-CHIP), which is found in the membranes of erythrocytes and renal epithelial cells of the proximal tubule. Further characterization of this protein indicates that Co a and Co b antigens correspond to the respective presence of alanine or valine at position 45 within the first extracellular loop of aquaporin-1 [16][17][18].…”

An Example of Anti‐Coa Found in Pregnancy

“…[2], described three examples of an antibody, anti-Co" (Colton), defining a previously unrecognised antigen, Co", present on the red cells of 99.7% of North Europeans. A further example of the antibody was reported by WRAY and SIMPSON [4] in 1968.…”

Survival of Homozygous Co^a (Colton) Red Cells in a Patient with Anti-Co^a

“…Anti-Coa, defining an antigen present in 99.7% of the Caucasian population, was de scribed by Heisto et al [3] in 1967, and other examples have been reported [6,9,10]. Al though this antibody has been associated with mild hemolytic disease of the newborn, its clinical importance has been question able [1,2,4], Survival of 5lCr homozygous Co(a+) cells was studied in a patient with anti-Coa and the results are reported.…”