A Further Illustration of Nearest-neighbour Auto-inhibitory Effects in the Oxidation of Alginate by Periodate Ion.

Painter, Terence; Larsen, Bjørn; Hessler, Gunnel; Liaaen‐Jensen, S.; Enzell, Curt R.; Swahn, Carl‐Gunnar

doi:10.3891/acta.chem.scand.27-1957

Cited by 28 publications

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“…In the FTIR analysis of oxi-pectin (Fig. 4A), the peak at 1740 cm À1 , which shifted to lower wavenumbers and became narrower, might contain the contribution of the vibrational symmetric stretching of aldehydic groups, as discussed in previous works on other polyuronates [29][30][31][32] or glycosaminoglycans. 33 Other peak modifications, probably associated with the absorption of aliphatic aldehydes, were visible in the region between 1440 cm À1 and 1350 cm À1 and refer to in-plane C-H rocking.…”

Section: Structural Modifications By Ftirmentioning

confidence: 52%

Biofunctional chemically modified pectin for cell delivery

et al. 2012

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To modulate cell adhesion and to improve the biodegradability of pectin for cell immobilization, two possible approaches of functionalization were investigated: oxidation with sodium periodate (oxipectin) and coupling with a RGD-containing oligopeptide (RGD-pectin). Modified pectin was characterized in terms of degree of esterification (DE), intrinsic viscosity, molecular weight, rheological properties, biological behaviour and structure. Pectin microspheres were prepared using these modified pectins and their swelling and stability were evaluated. A new method to determine the DE, based on colorimetry, is here proposed, showing a high correlation with the traditional method based on titration. Partial oxidation and RGD grafting were effective in modulating pectin microspheres degradation and cytocompatibility: RGD-pectin microspheres showed highest cytocompatibility, whereas oxi-pectin microspheres provided accelerated dissolution, which may be associated with faster in vivo release of cells. These biomaterials were proven to have potential interest as injectable cell delivery systems for tissue engineering and, in general, for regenerative medicine applications.

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Section: Structural Modifications By Ftirmentioning

confidence: 52%

Biofunctional chemically modified pectin for cell delivery

et al. 2012

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“…The partial oxidation of HA catalyzed by a periodate (NaIO 4 ) introduces aldehyde groups in HA glucuronic acid, providing opportunities for cross-linking with small metabolizable molecules such as adipic dihydrazide (ADH) by click reaction [19][20][21][22][23]. First, studies have used HA/ADH hydrogels for nucleus pulposus regeneration [24][25][26].…”

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confidence: 99%

Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

2021

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Hyaluronic acid (HA) is a natural polyelectrolyte abundant in mammalian connective tissues, such as cartilage and skin. Both endogenous and exogenous HA produced by fermentation have similar physicochemical, rheological, and biological properties, leading to medical and dermo-cosmetic products. Chemical modifications such as cross-linking or conjugation in target groups of the HA molecule improve its properties and in vivo stability, expanding its applications. Currently, HA-based scaffolds and matrices are of great interest in tissue engineering and regenerative medicine. However, the partial oxidation of the proximal hydroxyl groups in HA to electrophilic aldehydes mediated by periodate is still rarely investigated. The introduced aldehyde groups in the HA backbone allow spontaneous cross-linking with adipic dihydrazide (ADH), thermosensitivity, and noncytotoxicity to the hydrogels, which are advantageous for medical applications. This review provides an overview of the physicochemical properties of HA and its usual chemical modifications to better understand oxi-HA/ADH hydrogels, their functional properties modulated by the oxidation degree and ADH concentration, and the current clinical research. Finally, it discusses the development of biomaterials based on oxi-HA/ADH as a novel approach in tissue engineering and regenerative medicine.

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“…The experiments with soil, in which periodate treatment alternates with reduction with NaBH,, provide evidence for the formation of hemiacetals from the partial oxidation products of some sugars and their nearest neighbours. This is known to occur with 1-4 xylans (Painter & Larsen, 1970) as well as other polymers (Painter & Larsen, 1973) and could explain the persistence of 1-4 Xyl to the extent observed. The 1-3 linked xylose would be expected to persist because of a lack of vicinal hydroxyl groups.…”

Section: Discussionmentioning

confidence: 75%

Structure of soil carbohydrates resistant to periodate oxidation

Cheshire¹,

Lomax²,

Mundie³

1989

Journal of Soil Science

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SUMMARY Permethylation has been applied to the polysaccharide in soil, which has been oxidized with 0.2 m NaIO4 and treated with 0.1 m Na2B4O7. The amounts and types of methylated sugar obtained on hydrolysis have been compared with those from unoxidized soil. As well as a number of derivatives corresponding to 1 ‐3 linked glucose, arabinose and xylose, considerable proportions of 1‐4 linked glucose and xylose also persisted. The polysaccharides appear to persist for both chemical and physical reasons.

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A Further Illustration of Nearest-neighbour Auto-inhibitory Effects in the Oxidation of Alginate by Periodate Ion.

Cited by 28 publications

References 0 publications

Biofunctional chemically modified pectin for cell delivery

Biofunctional chemically modified pectin for cell delivery

Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

Structure of soil carbohydrates resistant to periodate oxidation

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