“…The development of instrumentation and automation for modern industrial processes in the chemical and general manufacturing industries allows large quantities of data to be utilized for assessing current operating conditions (Kruger & Xie, 2012;Severson, Chaiwatanodom & Braatz, 2016). Traditional approaches to monitor general processes include model-based (Ding, 2013;Zhong, Xue & Ding, 2018;Liu, Luo, Yang & Wu, 2016;Li, Gao, Shi & Lam, 2016;Zhao, Yang, Ding & Li, 2018), signal-based (Lei, Lin, He & Zuo, 2013;Yan, Gao & Chen, 2014;Fan, Cai, Zhu, Shen, Huang & Shang, 2015;Wu, Guo, Xie, Ni & Liu, 2018), and knowledge-based (Gao, Cecati & Ding, 2015;Mohammadi & Montazeri-Gh, 2015;Chiremsel, Corresponding Authors: +86-25-8489-3221, q.chen@nuaa.edu.cn (Qian Chen); +1-518-276-4818, krugeu@rpi.edu (Uwe Kruger) Said & Chiremsel, 2016;Davies, Jackson & Dunnett, 2017) techniques. Based on their conceptual simplicity, techniques that relate to multivariate statistical process control (MSPC) (Kruger & Xie, 2012;Qin, 2012;Ge, Song & Gao, 2013;Yin, Li, Gao & Kaynak, 2015) have also gained attention over the past few decades, particularly for applications to industrial processes that produce larger variable sets.…”