A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta-analysis

Wu, Jin; Guan, Xuan; Zhang, Kui; Li, Ya‐Ting; Bai, Peng

doi:10.3892/br.2013.131

Cited by 5 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these downstream target proteins, the cyclin D1 can regulate and control the cell transformation from G1 phase to S phase to interfere with the process of cell proliferation, by combining with cyclin-dependent kinase and activating it in G1 phase (24). MMP-7, a member of the family of matrix metalloproteinases, is not only involved in various extracellular matrix lysis, but also can damage diversified tumor-suppressor compositions on the cell surface (25). COX-2 can suppress tumor cell apoptosis, promote tumor cell proliferation, stimulate matrix metalloproteinases production and enhance tumor cell invasion and metastasis abilities (26).…”

Section: Discussionmentioning

confidence: 99%

The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway

Gai

Sheng

Qin

et al. 2015

International Journal of Oncology

View full text Add to dashboard Cite

Abstract. Hepatocellular carcinoma (HCC) is a highly malignant tumor with an extremely poor prognosis. Our preliminary study indicated that bufalin could restrain the proliferation of human hepatoma BEL-7402 cells in a time-and dosedependent manner. In the present study, the colony formation assay, the Transwell invasion assay, the western blot analysis and the immunofluorescence method were respectively used to investigate the effect and mechanism of bufalin against HCC cell invasion and metastasis. We found that: i) bufalin had significant inhibitory effect on the cell proliferation of BEL-7402 cells; ii) bufalin markedly inhibited the migration and invasion of BEL-7402 cells; iii) bufalin could suppress the phosphorylation of GSK-3β Ser9 site in BEL-7402 cells, decrease the expression of β-catenin, cyclin D1, metalloproteinases-7 (MMP-7) and cyclooxygenase-2 (COX-2) in the cytoplasm, and increase the expression of E-cadherin and β-catenin on the cell membrane; and iv) the expression of α-fetoprotein significantly decreased and the expression of albumin increased in BEL-7402 cells after bufalin was used. Our results indicate that: i) bufalin can regulate the expression of associated factors in Wnt/β-catenin signaling pathway of BEL-7402 cells through suppressing the phosphorylation of GSK-3β Ser9 site; ii) bufalin can strengthen intercellular E-cadherin/β-catenin complex to control epithelial-mesenchymal transition; and iii) bufalin can reverse the malignant phenotype and promote the differentiation and maturation by regulating the AFP and ALB expression in BEL-7402 cells. These are very important mechanisms of bufalin on the inhibition of the invasion and metastasis of HCC cells.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway

Gai

Sheng

Qin

et al. 2015

International Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…16 MMP-7 not only participates in various extracellular matrix lysis, but also damages diverse tumor suppressor compositions on the cell surface. 17 Consequently, the overexpression of cyclin D1, MMP-7, and COX-2 plays an essential role in the proliferation, invasion, and metastasis of hepatoma cells. 18 …”

Section: Effect and Mechanism Of Action Of Bufalin In Inhibiting Hepa...mentioning

confidence: 99%

The Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma

Jiang¹,

Zheng²,

Cheng³

et al. 2022

OTT

View full text Add to dashboard Cite

“…In colorectal cancer elevated MMP7 expression is a prognostic marker of overall survival [13, 14], associated with resistance to chemotherapy [14, 15], and increased metastasis to the liver [16]. In addition, mutations in the MMP7 promoter are associated with the increased risk of colorectal cancer [17–19]. In the mammary gland, MMP7 is expressed in the normal ductal and lobular epithelia and elevated expression of MMP7 at the mRNA level has been observed in some breast carcinomas [8, 20].…”

Section: Introductionmentioning

confidence: 99%

Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors

Sizemore

Booth

et al. 2014

Breast Cancer Res Treat

View full text Add to dashboard Cite

Identification of novel targets for the treatment of basal-like breast cancer is essential for improved outcomes in patients with this disease. This study investigates the association of MMP7 expression and MMP7 promoter methylation with subtype and outcome in breast cancer patient cohorts. Immunohistochemical analysis was performed on a breast cancer tissue microarray and validated in independent histological samples. MMP7 expression significantly correlated with patient age, tumor size, triple-negative (TN) status, and recurrence. Analysis of publically available datasets confirmed MMP7 gene expression as a prognostic marker of breast cancer metastasis, particularly metastasis to the brain and lungs. Methylation of the MMP7 promoter was assessed by methylation-specific PCR in a panel of breast cancer cell lines and patient tumor samples. Hypomethylation of the MMP7 promoter significantly correlated with TN status in DNA from patient tumor samples, and this association was confirmed using The Cancer Genome Atlas (TCGA) dataset. Evaluation of a panel of breast cancer cell lines and data from the Curtis and TCGA breast carcinoma datasets revealed that elevated MMP7 expression and MMP7 promoter hypomethylation are specific biomarkers of the basal-like molecular subtype which shares considerable, but not complete, overlap with the clinical TN subtype. Importantly, MMP7 expression was identified as an independent predictor of pathological complete response in a large breast cancer patient cohort. Combined, these data suggest that MMP7 expression and MMP7 promoter methylation may be useful as prognostic biomarkers. Furthermore, MMP7 expression and promoter methylation analysis may be effective mechanisms to distinguish basal-like breast cancers from other triple-negative subtypes. Finally, these data implicate MMP7 as a potential therapeutic target for the treatment of basal-like breast cancers.

show abstract

A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta-analysis

Cited by 5 publications

References 31 publications

The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway

The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway

The Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma

Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors

Contact Info

Product

Resources

About