2017
DOI: 10.1002/2211-5463.12270
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A G protein‐coupled α7 nicotinic receptor regulates signaling and TNF‐α release in microglia

Abstract: Acetylcholine activation of α7 nicotinic acetylcholine receptors (α7 nAChR s) in microglia attenuates neuroinflammation and regulates TNF ‐α release. We used lipopolysaccharide to model inflammation in the microglial cell line EOC 20 and examined signaling by the α7 nAChR . Co‐immunoprecipitation experiments confirm that α7 nAChR s bind heterotrimeric G proteins in EOC 20 ce… Show more

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Cited by 67 publications
(55 citation statements)
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“…There are multiple cell types in the hippocampus that express functional α7 nAChRs, including interneurons, astrocytes, microglia as well as immature granule cells (John et al 2015; Jones and Yakel 1997; King et al 2017; Sharma and Vijayaraghavan 2001; Shen and Yakel 2012; Shytle et al 2004). We investigated if the loss of α7 nAChRs in nestin + NSCs prior to or during adult neurogenesis was responsible for the changes in adult neurogenesis we had seen in male (but not female) mice; that is whether these changes are a result of cell autonomous or simple feed-back regulation.…”
Section: Resultsmentioning
confidence: 99%
“…There are multiple cell types in the hippocampus that express functional α7 nAChRs, including interneurons, astrocytes, microglia as well as immature granule cells (John et al 2015; Jones and Yakel 1997; King et al 2017; Sharma and Vijayaraghavan 2001; Shen and Yakel 2012; Shytle et al 2004). We investigated if the loss of α7 nAChRs in nestin + NSCs prior to or during adult neurogenesis was responsible for the changes in adult neurogenesis we had seen in male (but not female) mice; that is whether these changes are a result of cell autonomous or simple feed-back regulation.…”
Section: Resultsmentioning
confidence: 99%
“…Nicotinic receptors, in particular α7 receptor (Y. Sun et al, ; King, Gillevet, & Kabbani, ), decreases p‐NF‐κB and its p65 subunit and inhibits p38 mitogen‐activated protein kinase (p38‐MAPK), a key player of inflammatory microglia response (Lawson, Dobrikova, Shveygert, & Gromeier, ) (Figure ), while upregulates antioxidant genes, promoting a pro‐regenerative microglial state (Z. Han et al, ). Sphingosine‐1‐phosphate (S1P) receptors downregulate pro‐inflammatory cytokines and enhance pro‐regenerative responses after intracerebral hemorrhage (Marfia et al, ; Noda, Takeuchi, Mizuno, & Suzumura, ).…”
Section: Receptor and Channels Promoting Anti‐inflammatory Microglia mentioning
confidence: 99%
“…Nicotinic receptors, in particular α7 receptor (Y. Sun et al, 2013;King, Gillevet, & Kabbani, 2017), decreases p-NF-κB and its p65 subunit and inhibits p38 mitogen-activated protein kinase (p38-MAPK), a key player of inflammatory microglia response (Lawson, Dobrikova, Shveygert, & Gromeier, 2013) (Figure 1), while upregulates antioxidant genes, promoting a pro-regenerative microglial state (Z. Han et al, 2014).…”
Section: Histamine and Other Neurotransmitter Receptorsmentioning
confidence: 99%
“…In contrast, nicotine suppresses reactive microglia in the adult brain (Li et al, 2016;Noda & Kobayashi, 2017), and blocks LPS-induced increases in microglial activation and expression of Toll-like receptor 4 (TLR4, see below; Kim et al, 2014;Li et al, 2016). The anti-inflammatory state produced by nicotine results from activation of the a7 nicotinic acetylcholine receptor (nAChR) (Shytle et al, 2004;Noda & Kobayashi, 2017), possibly in a metabotropic signaling mode (King et al, 2017). Astrocytes have also been shown to express a7 nAChRs (Shen & Yakel, 2012), which modulate synaptic responsiveness by controlling glial release of the N-methyl D-aspartate (NMDA) receptor co-agonist, D-serine (Papouin et al, 2017).…”
Section: Drugs Of Abuse Promote Reactive Gliamentioning
confidence: 99%