A GABAergic inhibitory component within the hippocampal commissural pathway

Ribak, Ce; Seress, László; Peterson, GM; Seroogy, Kb; Jh, Fallon; Schmued, LC

doi:10.1523/jneurosci.06-12-03492.1986

Cited by 116 publications

(64 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Scharfman (1995) has also demonstrated that mossy cells innervate both granule cells and GABAergic interneurons. It should also be noted for the sake of completeness that a small component of the commissural connection in the rat does appear to arise from GABAergic neurons (Ribak et al, 1986). …”

Section: Mossy Cell Projectionsmentioning

confidence: 99%

The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)

Amaral

Scharfman

Lavenex

2007

Progress in Brain Research

739

690

View full text Add to dashboard Cite

The dentate gyrus is a simple cortical region that is an integral portion of the larger functional brain system called the hippocampal formation. In this review, the fundamental neuroanatomical organization of the dentate gyrus is described, including principal cell types and their connectivity, and a summary of the major extrinsic inputs of the dentate gyrus is provided. Together, this information provides essential information that can serve as an introduction to the dentate gyrusa "dentate gyrus for dummies."

show abstract

Section: Mossy Cell Projectionsmentioning

confidence: 99%

The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)

Amaral

Scharfman

Lavenex

2007

Progress in Brain Research

739

690

View full text Add to dashboard Cite

show abstract

“…Because it is not possible to distinguish mossy cells from neighboring hilar interneurons by morphology alone on the basis of the IR-DIC image and there is no genetic or other marker that labels living mossy cells, we developed a technique to visualize mossy cells for cell-specific ablation experiments. We took advantage of the fact that mossy cells have an extensive contralateral projection (Ribak et al, 1985;Frotscher et al, 1991;Blasco-Ibanez and Freund, 1997) and most of the axons from hilar interneurons are confined to the ipsilateral side (Ribak et al, 1986). To achieve selective mossy cell labeling on the ipsilateral side, the fluorescent dye DiO was injected into the contralateral (right) hippocampus (see Materials and Methods) ( Fig.…”

Section: Prelabeling and Visualization Of Mossy Cells In Living Slicesmentioning

confidence: 99%

Rapid Deletion of Mossy Cells Does Not Result in a Hyperexcitable Dentate Gyrus: Implications for Epileptogenesis

Ratzliff¹,

Howard²,

Santhakumar³

et al. 2004

J. Neurosci.

109

View full text Add to dashboard Cite

Loss of cells from the hilus of the dentate gyrus is a major histological hallmark of human temporal lobe epilepsy. Hilar mossy cells, in particular, are thought to show dramatic numerical reductions in pathological conditions, and one prominent theory of epileptogenesis is based on the assumption that mossy cell loss directly results in granule cell hyperexcitability. However, whether it is the disappearance of hilar mossy cells from the dentate gyrus circuitry after various insults or the subsequent synaptic-cellular alterations (e.g., reactive axonal sprouting) that lead to dentate hyperexcitability has not been rigorously tested, because of the lack of available techniques to rapidly remove specific classes of nonprincipal cells from neuronal networks.We developed a fast, cell-specific ablation technique that allowed the targeted lesioning of either mossy cells or GABAergic interneurons in horizontal as well as axial (longitudinal) slices of the hippocampus. The results demonstrate that mossy cell deletion consistently decreased the excitability of granule cells to perforant path stimulation both within and outside of the lamella where the mossy cell ablation took place. In contrast, ablation of interneurons caused the expected increase in excitability, and control aspirations of the hilar neuropil or of interneurons in the presence of GABA receptor blockers caused no alteration in granule cell excitability.These data do not support the hypothesis that loss of mossy cells from the dentate hilus after seizures or traumatic brain injury directly results in hyperexcitability.

show abstract

“…Because several dentate interneurons, including basket cells, are long-range projection cells, GABA or glutamic acid decarboxylase (GAD) immunocytochemistry cannot be used for these experiments, because of the low and variable levels of GABA and GAD immunoreactivity present in GABAergic cells with distant projections. Colchicine injections can enhance the staining, but the interpretation of any quantitative data obtained from the colchicine-treated animals would be difficult (Ribak et al, 1986;Miettinen et al, 1992;Tóth et al, 1993;Freund and Buzsáki, 1996). Therefore, we used the SPR antibody (courtesy of Dr. Shigemoto) to ascertain the posttraumatic status of the non-PV-and non-CCK-positive interneurons in the granule cell layer.…”

Section: Modification Of the Initial "Physical" Injury Pattern At Lamentioning

confidence: 99%

Instantaneous Perturbation of Dentate Interneuronal Networks by a Pressure Wave-Transient Delivered to the Neocortex

et al. 1997

View full text Add to dashboard Cite

Whole-cell patch-clamp recordings and immunocytochemical experiments were performed to determine the short-and longterm effects of lateral fluid percussion head injury on the perisomatic inhibitory control of dentate granule cells in the adult rat, with special reference to the development of traumainduced hyperexcitability. One week after the delivery of a single, moderate (2.0-2.2 atm) mechanical pressure wave to the neocortex, the feed-forward inhibitory control of dentate granule cell discharges was compromised, and the frequency of miniature IPSCs was decreased. Consistent with the electrophysiological data, the number of hilar parvalbumin (PV)-and cholecystokinin (CCK)-positive dentate interneurons supplying the inhibitory innervation of the perisomatic region of granule cells was decreased weeks and months after head injury. The initial injury to the hilar neurons took place instantaneously after the impact and did not require the recruitment of active physiological processes. Furthermore, the decrease in the number of PV-and CCK-positive hilar interneurons was similar to the decrease in the number of the AMPA-type glutamate receptor subunit 2/3-immunoreactive mossy cells, indicating that the pressure wave-transient causes injurious physical stretching and bending of most cells that are large and not tightly packed in a cell layer.These results reveal for the first time that moderate pressure wave-transients, triggered by traumatic head injury episodes, impact the dentate neuronal network in a unique temporal and spatial pattern, resulting in a net decrease in the perisomatic control of granule cell discharges.

show abstract

A GABAergic inhibitory component within the hippocampal commissural pathway

Cited by 116 publications

References 28 publications

The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)

The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)

Rapid Deletion of Mossy Cells Does Not Result in a Hyperexcitable Dentate Gyrus: Implications for Epileptogenesis

Instantaneous Perturbation of Dentate Interneuronal Networks by a Pressure Wave-Transient Delivered to the Neocortex

Contact Info

Product

Resources

About