A gadolinium-based magnetic resonance imaging contrast agent for nucleotides sensing

Kong, Jichuan; Liu, Zhengkang; Cai, Dongxu; Fan, Yun-Chang; Zhao, Peiran; Liu, Xing; Pu, Peiyu; Song, Lingguang; He, Cheng

doi:10.1016/j.snb.2017.10.026

Cited by 14 publications

(3 citation statements)

References 47 publications

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“…When we increased the dose of GdPO 4 :Tb-EDTA to 3 mg [Gd]/kg, no tissue injury or inflammation was found associated with the administration of as prepared nanocontrast agent (Figure ). Also, there was no obvious increase in lymphocyte, macrophage, neutrophil, or eosinophil cell counts compared to the control samples. ,,, On the basis of the above results, we concluded that GdPO 4 :Tb-EDTA was safe for MR imaging in vivo .…”

Section: Resultsmentioning

confidence: 57%

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GdPO₄-Based Nanoprobe for Bioimaging and Selective Recognition of Dipicolinic Acid and Cysteine by a Sensing Ensemble Approach

Shen

Jia

et al. 2018

ACS Biomater. Sci. Eng.

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Multiple functions incorporated in one single-component nanoplatform pave the way for important biomedicine applications. Herein, a multifunctional terbium-doped gadolinium orthophosphate (GdPO4:Tb-EDTA) nanoplatform was prepared through a simple, ecofriendly, one-step hydrothermal method. Results showed that dipicolinic acid (DPA), the biomarker of bacterial spores, significantly increased the fluorescence intensity of this nanoplatform and conferred it with rapid response and excellent selectivity. Subsequently, the fluorescence of the ensemble GdPO4:Tb-EDTA-DPA can be remarkably quenched by Cu2+, which led to a rewritable nanosensor used in the detection of cysteine (Cys) with excellent sensitivity. In addition, GdPO4:Tb-EDTA can also be a potential T 1-weighted magnetic resonance imaging (MRI) contrast agent, which indicated a satisfactory in vitro MRI with r 1 relaxivity values of 13.9 mM–1 s–1 and in vivo MRI through intravenous administration on a rat model. Overall, the proposed assay may have great theoretical and practical significance for designing multifunctional biomaterials.

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Section: Resultsmentioning

confidence: 57%

“…Also, there was no obvious increase in lymphocyte, macrophage, neutrophil, or eosinophil cell counts compared to the control samples. 22,49,60,61 On the basis of the above results, we concluded that GdPO 4 :Tb-EDTA was safe for MR imaging in vivo.…”

Section: Acs Biomaterials Science and Engineeringmentioning

confidence: 62%

GdPO₄-Based Nanoprobe for Bioimaging and Selective Recognition of Dipicolinic Acid and Cysteine by a Sensing Ensemble Approach

Shen

Jia

et al. 2018

ACS Biomater. Sci. Eng.

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“…Pr has paramagnetic properties [53], FAP-Pr nanocrystals can be a potential contrast agent for MRI imaging. Compared to typical Gd-based agents, biocompatibility of FAP matrix doped with Pr is a high advantage [52].…”

Section: Cell Uptake Of Fap-pr Nanoparticlesmentioning

confidence: 99%

Fabrication and characterization of luminescent Pr3+ doped fluorapatite nanocrystals as bioimaging contrast agents

Milojkov

Silvestre

Stanić

et al. 2020

Journal of Luminescence

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Biofuel‐Driven Stepping Chiral Supramolecular Transfer Container

Yu,

Qiu

et al. 2024

Angewandte Chemie

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Herein, we reported a biofuel‐driven recyclable chiral supramolecular transfer container based on hexacationic triphenylamine cage and nucleotides. Possessing rotatable paddle rigid backbones, the artificial receptor effectively encapsulated nucleotides with a high binding constant up to 5.37×105 M‐1 in water, displaying guest‐induced efficient fluorescence enhancement with quantum yield increased from 6.5% to 16.6%. Especially, the achiral cage could effectively bind with adenosine triphosphate to activate chirality transfer from substrates to the single molecular container, giving circularly polarized luminescence at 575 nm and positive Cotton effect peaks with significant asymmetric factor (gabs = +6.4×10‐4). Meanwhile, the adaptive chiral supramolecule not only has reversible thermal responsiveness but also could stepwise regulate chirality transfer by the catalysis of hexokinase and apyrase in tandem, showing recovery adaptive chirality after refueled, achieving dynamically regulated programmable multistate chiral luminescent supramolecules. Therefore, the biofuel‐driven chiral supramolecular transfer container could be successfully applied in chiral logic gates and multilevel information encryption, providing new insight into intelligent chiral materials.

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A gadolinium-based magnetic resonance imaging contrast agent for nucleotides sensing

Cited by 14 publications

References 47 publications

GdPO₄-Based Nanoprobe for Bioimaging and Selective Recognition of Dipicolinic Acid and Cysteine by a Sensing Ensemble Approach

GdPO₄-Based Nanoprobe for Bioimaging and Selective Recognition of Dipicolinic Acid and Cysteine by a Sensing Ensemble Approach

Fabrication and characterization of luminescent Pr3+ doped fluorapatite nanocrystals as bioimaging contrast agents

Biofuel‐Driven Stepping Chiral Supramolecular Transfer Container

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A gadolinium-based magnetic resonance imaging contrast agent for nucleotides sensing

Cited by 14 publications

References 47 publications

GdPO4-Based Nanoprobe for Bioimaging and Selective Recognition of Dipicolinic Acid and Cysteine by a Sensing Ensemble Approach

GdPO4-Based Nanoprobe for Bioimaging and Selective Recognition of Dipicolinic Acid and Cysteine by a Sensing Ensemble Approach

Fabrication and characterization of luminescent Pr3+ doped fluorapatite nanocrystals as bioimaging contrast agents

Biofuel‐Driven Stepping Chiral Supramolecular Transfer Container

Contact Info

Product

Resources

About

GdPO₄-Based Nanoprobe for Bioimaging and Selective Recognition of Dipicolinic Acid and Cysteine by a Sensing Ensemble Approach

GdPO₄-Based Nanoprobe for Bioimaging and Selective Recognition of Dipicolinic Acid and Cysteine by a Sensing Ensemble Approach