2020
DOI: 10.1038/s41385-020-0293-7
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A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies

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Cited by 6 publications
(3 citation statements)
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“…7). A similar boost of heterologous immunity was recently made in the context of other viral infections by our group (38). Considering these observations, development of vectored-vaccines based on replication competent AdVs could also be advantageous for an improved T cell immune response.…”
Section: Discussionsupporting
confidence: 61%
“…7). A similar boost of heterologous immunity was recently made in the context of other viral infections by our group (38). Considering these observations, development of vectored-vaccines based on replication competent AdVs could also be advantageous for an improved T cell immune response.…”
Section: Discussionsupporting
confidence: 61%
“…Activation and proliferation of antigen-independent bystander CD8 + T cells and their function during subsequent infections have remained controversial. Though some studies have assigned them a role during viral infections [35,36], other studies suggested that bystander activation of CD8 + T cells is insignificant in terms of functional roles [37][38][39][40]. Recently, however, studies have demonstrated that the host priming by a pathogen induced a long-term infiltration of CD8 + T cells in the lungs.…”
Section: Discussionmentioning
confidence: 99%
“…MuHV-4 infection has been shown to train immunity against various heterologous infections ( 54 , 55 ). In addition to triggering regulatory pathways to dampen specific antiviral defenses, γHVs license CD8 ( 56 ), and potentially CD4, T cells to protect their own niche against heterologous pathogens. Here, we provide evidence supporting a role for γHV-imprinted MOs in the activation of CD4 T cells while finely regulating their cytotoxic and degranulation capacities.…”
Section: Discussionmentioning
confidence: 99%