Trace isotope determination techniques based on resonant optical excitation of atoms, i.e. resonance ionization mass spectrometry, are well known. Especially concerning the determination of low level contaminations of long-lived radioactive isotopes in environmental or technical samples, outstanding specifications have been demonstrated. Nevertheless, there is still an -even increasing -deficiency in the routine application of these techniques. This fact is ascribed to the complexity of operation and the still only limited reliability of the tunable laser systems in use. While fixed frequency lasers have widely conquered almost all fields of basic and applied research and development, the application of tunable and particularly narrow band width lasers is almost exclusively limited to the delicate fields of fundamental research and quantum optical investigations. Thus, routine investigations in the field of isotope sciences are still the domain of all kind of conventional radiometric, mass spectrometric or alternative optical techniques, but widely excluding resonant optical interaction. This review will discuss the state of the art of these resonant laser techniques developed with special emphasis on elemental isotope selective determination techniques, elucidate reasons for the slight stagnation observed in this field and stimulate further possible developments and applications.