A Gastric Follicular Lymphoma Presenting as a Submucosal Tumor with a Diagnosis Determined by Endoscopic Resection

Fujimoto, Ai; Akimoto, Teppei; Nakayama, Atsushi; Mikami, Shuji; Tsujikawa, Hanako; Kameyama, Kaori; Okamoto, Shinichiro; Maehata, Tadateru; Ochiai, Yasutoshi; Goto, Osamu; Kato, Motohiko; Sasaki, Motoki; Uraoka, Toshio; Yahagi, Naohisa

doi:10.2169/internalmedicine.0069-17

Cited by 2 publications

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“…Primary gastrointestinal follicular lymphomas (PGFL) represent a very rare entity, whose frequency in different clinicopathological series of primary gastrointestinal lymphomas varied from 3% to 13%. [1][2][3][4] The clinical and biological characteristics of these Primary Gastrointestinal Follicular Lymphomas: A Prospective Study of 31 Patients with Long-term Follow-up Registered in the French Gastrointestinal Lymphoma Study Group (GELD) of the French Federation of Digestive Oncology (FFCD) lymphomas are not well known, and have been described mainly through clinical cases [5][6][7][8][9] and some clinicopathological series, usually retrospective, reported in the literature. [10][11][12][13][14][15][16][17][18] Due to their rarity and lack of randomized trials, the treatment of PGFL is not standardized.…”

Section: Introductionmentioning

confidence: 99%

Primary Gastrointestinal Follicular Lymphomas: A Prospective Study of 31 Patients with Long-term Follow-up Registered in the French Gastrointestinal Lymphoma Study Group (GELD) of the French Federation of Digestive Oncology (FFCD)

et al. 2022

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Background/Aims: Primary gastrointestinal follicular lymphomas (PGFL) are very rare. Our aim was to analyze the clinical features, management, and long-term outcomes in a prospective series of patients diagnosed with PGFL. Methods:All adult patients with PGFL, consecutively enrolled into the multicenter French study between 1990 and 2017, were evaluated and followed up prospectively after undergoing a complete work-up. Clinical, pathological and endoscopic features, as well as treatment outcomes, were analyzed.Results: Thirty-one patients (16 men, median age 62 years, range 33 to 79 years) with PGFL were included. The median follow-up was 92 months (range, 6 to 218 months). In the majority of patients (n=14), lymphoma was incidentally diagnosed during endoscopy. Otherwise, the most frequent circumstances of diagnosis were abdominal pain (n=7) and dyspepsia (n=5). The duodenum was the most common site of involvement (n=19) and multifocal localizations were seen in seven patients (22%). The most frequent first line strategy was surveillance applied in 22 patients (71%), of whom nine reached spontaneous, complete remission and 11 had stable disease. Seven patients (23%) received chemotherapy as first line treatment, and two underwent resection. Of seven patients who received chemotherapy, four achieved complete remission. In three patients, transformation into a high-grade lymphoma occurred. Conclusions:The diagnosis of PGFL is frequently fortuitous. The most common localization is in the duodenum. The disease has an indolent course and a good prognosis, however, rare cases of transformation into aggressive high-grade lymphoma may occur. An appropriate characterization and follow-up of these lymphomas is mandatory for their optimal management. (Gut Liver,

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Section: Introductionmentioning

confidence: 99%

Primary Gastrointestinal Follicular Lymphomas: A Prospective Study of 31 Patients with Long-term Follow-up Registered in the French Gastrointestinal Lymphoma Study Group (GELD) of the French Federation of Digestive Oncology (FFCD)

et al. 2022

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“… 3 Endoscopic submucosal dissection may be selected for histologic diagnosis. 4 Although FL is known to have t(14:18) chromosomal translocation, the positive rate in gastric FL is less frequent than that in nodal FL and small intestinal FL. 5 Gastric FL is a rare disease, and its macroscopic and pathophysiologic findings are different from those of FL in the small intestine.…”

Section: Case Reportmentioning

confidence: 99%