A Gd-doped Mg-Al-LDH/Au nanocomposite for CT/MR bimodal imagings and simultaneous drug delivery

Wang, Lijun; Xing, Haibo; Zhang, Shengjian; Ren, Qingguo; Pan, Limin; Zhang, Kun; Bu, Wenbo; Zheng, Xiangpeng; Zhou, Lei; Peng, Weijun; Hua, Yanqing; Shi, Jianlin

doi:10.1016/j.biomaterials.2013.01.070

Cited by 171 publications

(138 citation statements)

References 59 publications

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“…13C). 18 By culturing mouse fibroblastic cell lines and human cervical cancer cell lines in vitro, the authors showed enhanced doxorubicin delivery efficiency with LDH-Gd@Au compared with free doxorubicin (Fig. 13D).…”

Section: Metal Nanoparticle Dot-coated Ldhmentioning

confidence: 95%

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Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

2015

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a Layered double hydroxide (LDH)-based nanocomposites, constructed by interacting LDH nanoparticles with other nanomaterials (e.g. silica nanoparticles and magnetic nanoparticles) or polymeric molecules (e.g. proteins), are an emerging yet active area in healthcare, environmental remediation, energy conversion and storage.Combining advantages of each component in the structure and functions, hierarchical LDH-based nanocomposites have shown great potential in biomedicine, water purification, and energy storage and conversion.This feature article summarises the recent advances in LDH-based nanocomposites, focusing on their synthesis, structure, and application in drug delivery, bio-imaging, water purification, supercapacitors, and catalysis.

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Section: Metal Nanoparticle Dot-coated Ldhmentioning

confidence: 95%

“…13D). 18 Meanwhile, thanks to the component of Gd 3+ and Au, the LDH-Gd@Au nanocomposite acted efficiently as a dual-functional contrast agent for magnetic resonance imaging and X-ray computed tomography imaging in a tumour-bearing mice model (Fig. 13E).…”

Section: Metal Nanoparticle Dot-coated Ldhmentioning

confidence: 98%

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

2015

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“…Riaz and Ashaf [85] have given a short review of recent research into the intercalation and delivery of anti-cancer drugs using LDHs. To date, LDHs have been utilized as nanocarriers for many anti-cancer drugs, such as folinic acid [48], methotrexate [48,50,86,87,88,89,90,91,92,93], 5-flourouracil [94,95,96,97] and doxifluridine [17], comptothecin [98,99,100], K 7 [PTiW 10 O 40 ]·6H 2 O [101], podophyllotoxin [102], and doxorubicin [103]. …”

Section: Drug–ldh Ddsmentioning

confidence: 99%

“…Shi et al [103] developed a Gd 3+ ions (magnetic resonance imaging (MRI) contrast agent) doped LDH/Au (computed tomography (CT) contrast agent) nanocomposite as both a drug carrier and a diagnostic agent. The LDH–Gd/Au nanocomposite have a high surface area (112.9 m 2 ·g −1 ), and thus high loading (264 mg (DOX)/g carrier) of the non-anionic anti-cancer drug doxorubicin by hydrogen bonding interaction, and the loaded DOX shows an interesting pH-responsive release, which is favorable for avoiding quick drug release in neutral blood system but promoting drug release at acidic tumor sites or within cells.…”

Section: Drug–ldh Ddsmentioning

confidence: 99%

Layered Double Hydroxide-Based Nanocarriers for Drug Delivery

2014

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Biocompatible clay materials have attracted particular attention as the efficient drug delivery systems (DDS). In this article, we review developments in the use of layered double hydroxides (LDHs) for controlled drug release and delivery. We show how advances in the ability to synthesize intercalated structures have a significant influence on the development of new applications of these materials. We also show how modification and/or functionalization can lead to new biotechnological and biomedical applications. This review highlights the most recent progresses in research on LDH-based controlled drug delivery systems, focusing mainly on: (i) DDS with cardiovascular drugs as guests; (ii) DDS with anti-inflammatory drugs as guests; and (iii) DDS with anti-cancer drugs as guests. Finally, future prospects for LDH-based drug carriers are also discussed.

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“…In detail, owing to lack of sufficient understanding and rational cost-to-benefit analysis for each imaging approach, previous organizations of different imaging modalities are usually arbitrary, [13][14][15] e.g., Liu et al prepared multifunctional NaYF 4 :Yb, Er@mSiO 2 @Fe 3 O 4 -PEG nanoparticles for UCL/MR bioimaging, 15 but SiO 2 coating impeded light transmission and resulted in reduced fluorescence intensity in comparison to free UCNP nanoparticles, 16 In this report, with in-depth understanding of each operation principle, ultrasound, CT and MR are selected to acquire the complete information of caners via exerting their personal advantages. 18,19 Differing from the previous design strategy of CAs, namely simple assembly of building blocks, a novel design strategy, marriage of structure and composition designs has been developed. Moreover, a sequential self-reduction reaction (SSR) synthetic approach has been well established to fabricate a biocompatible US&MR&CT 'all in one' trimodal imaging probe …”

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confidence: 99%

Marriage Strategy of Structure and Composition Designs for Intensifying Ultrasound & MR & CT Trimodal Contrast Imaging

Zhang

Chen

et al. 2015

ACS Appl. Mater. Interfaces

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Despite great efforts having been devoted to the design of multimodal imaging probe, almost all design principles of nanotheranostic agents subordinate to simple assemblies of building blocks, resulting in complex preparation process and discounted ability, that is, 1 + 1 < 2. In this report, a novel design strategy, marriage of structure design and composition design that can maximize imaging ability of each building block, ultimately achieving 1 + 1 ≥ 2, has been established. Moreover, a high-efficient ultrasound (US) & MR & CT trimodal contrast agent acts as model to instantiate this design strategy, wherein nanoparticles-induced nonlinear scattering and rattle-type structure-induced double scattering enhancing US imaging, and uniform distribution of Mn(2+) paramagentic centers and "core-satellite" structure of Au atoms favoring enhanced MR imaging and CT imaging, respectively have been validated, achieving optimization of structure design. Importantly, the selected components, silica, Au and MnO are endowed with excellent biocompatibility, displaying the marriage strategy of composition design with aforementioned structure optimization. In in vivo evaluations, such a biocompatible trimodal probe is demonstrated of excellent performance in intensifying CT, MR and US imaging in vivo, especially after positively charged modification by PEI promoting more probes retained in tumor. More importantly, as a universal design strategy, the involved principles in constructing such a US&MR&CT trimodal imaging probe promise great potentials in guiding designs of other materials-based multimodal imaging probe.

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A Gd-doped Mg-Al-LDH/Au nanocomposite for CT/MR bimodal imagings and simultaneous drug delivery

Cited by 171 publications

References 59 publications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Layered Double Hydroxide-Based Nanocarriers for Drug Delivery

Marriage Strategy of Structure and Composition Designs for Intensifying Ultrasound & MR & CT Trimodal Contrast Imaging

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