A Gene Expression Screen in<i>Drosophila melanogaster</i>Identifies Novel JAK/STAT and EGFR Targets During Oogenesis

Wittes, Julia; Schüpbach, Trudi

doi:10.1534/g3.118.200786

Cited by 31 publications

(22 citation statements)

References 98 publications

(100 reference statements)

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“…Another gene, kekkon1 , is a transmembrane protein known to regulate the activity of the epidermal growth factor receptor during oogenesis in Drosophila (Ghiglione et al. 1999; Wittes and Schüpbach 2019).…”

Section: Resultsmentioning

confidence: 99%

Rapid local adaptation linked with phenotypic plasticity

et al. 2020

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Models of "plasticity-first" evolution are attractive because they explain the rapid evolution of new complex adaptations. Nevertheless, it is unclear whether plasticity can facilitate rapid microevolutionary change between diverging populations. Here, we show how plasticity may have generated adaptive differences in fecundity between neighboring wild populations of burying beetles Nicrophorus vespilloides. These populations occupy distinct Cambridgeshire woodlands that are just 2.5 km apart and that probably originated from a common ancestral population about 1000-4000 years ago. We find that populations are divergently adapted to breed on differently sized carrion. Adaptive differences in clutch size and egg size are associated with divergence at loci connected with oogenesis. The populations differ specifically in the elevation of the reaction norm linking clutch size to carrion size (i.e., genetic accommodation), and in the likelihood that surplus offspring will be lost after hatching. We suggest that these two processes may have facilitated rapid local adaptation on a fine-grained spatial scale.

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Section: Resultsmentioning

confidence: 99%

Rapid local adaptation linked with phenotypic plasticity

et al. 2020

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“…6F, S6F), which is a marker of central main body follicle cells in Stages 6-8, 50,51 and cells in Cluster 1.0.1 express midline (mid) and pointed (pnt), which are markers of posterior follicle cells (Fig. 6I-J, S6G-H, S7B) [52][53][54][55][56]. The two mirr + clusters (Clusters 1.1.0 and 1.0.0) are distinguished from each other by temporal changes in gene expression, with Cluster 1.0.0 enriched for cells expressing Yp1, which is first expressed from Stage 7(Fig.…”

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confidence: 99%

A Single-Cell Atlas and Lineage Analysis of the Adult Drosophila Ovary

Rust

Byrnes

Yu³

et al. 2019

Preprint

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The Drosophila ovary is a widely used model for germ cell and somatic tissue biology. We have used single-cell RNA-sequencing to build a comprehensive cell atlas of the adult Drosophila ovary containing unique transcriptional profiles for every major cell type in the ovary, including the germline and follicle stem cells. Using this atlas we identify novel tools for identification and manipulation of known and novel cell types and perform lineage tracing to test cellular relationships of previously unknown cell types. By this we discovered a new form of cellular plasticity in which inner germarial sheath cells convert to follicle stem cells in response to starvation. Graphical AbstractManuscript (Page 3 of 31)

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“…This pathway has been observed to bolster RTK signal outputs and mediate crosstalk between other pathways. Some examples of this include Drosophila EGFR [37,38], PDGFR [39], and Drosophila Torso [40].…”

Section: Rtk Structure Function and Signalingmentioning

confidence: 99%

Receptor Tyrosine Kinases in Development: Insights from Drosophila

Mele

Johnson

2019

IJMS

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Cell-to-cell communication mediates a plethora of cellular decisions and behaviors that are crucial for the correct and robust development of multicellular organisms. Many of these signals are encoded in secreted hormones or growth factors that bind to and activate cell surface receptors, to transmit the cue intracellularly. One of the major superfamilies of cell surface receptors are the receptor tyrosine kinases (RTKs). For nearly half a century RTKs have been the focus of intensive study due to their ability to alter fundamental aspects of cell biology, such as cell proliferation, growth, and shape, and because of their central importance in diseases such as cancer. Studies in model organisms such a Drosophila melanogaster have proved invaluable for identifying new conserved RTK pathway components, delineating their contributions, and for the discovery of conserved mechanisms that control RTK-signaling events. Here we provide a brief overview of the RTK superfamily and the general mechanisms used in their regulation. We further highlight the functions of several RTKs that govern distinct cell-fate decisions in Drosophila and explore how their activities are developmentally controlled.

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A Gene Expression Screen inDrosophila melanogasterIdentifies Novel JAK/STAT and EGFR Targets During Oogenesis

Cited by 31 publications

References 98 publications

Rapid local adaptation linked with phenotypic plasticity

Rapid local adaptation linked with phenotypic plasticity

A Single-Cell Atlas and Lineage Analysis of the Adult Drosophila Ovary

Receptor Tyrosine Kinases in Development: Insights from Drosophila

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