A gene variant in the Atp10d gene associates with atherosclerotic indices in Japanese elderly population

Abstract

The rs2351791 SNP in the Atp10d gene affects the susceptibility for cardiac and intracranial vascular stenosis in the elderly Japanese population.

Behavioral and transcriptomic profiling of mice null forLphn3, a gene implicated inADHDand addiction

“…Overexpressed genes include two RIKEN cDNAs with unknown functions, Cox18 (a cytochrome c oxidase assembly protein important for assembly of complex IV of the mitochondrial respiratory chain), Atp10d (which belongs to a subfamily of P‐type ATPases implicated in phospholipid translocation from the exoplasmic to the cytoplasmic leaflet of cellular biological membranes, and which has been associated with atherosclerotic indices (Kengia et al. )), and Ociad1 (a cancer‐specific protein that was identified by immunoscreening of an ovarian carcinoma cDNA expression library (Luo et al. )).…”

Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease

“…Three genes, AHNAK, ADGRF5/GPR116, and ATP10D, reported to regulate obesity (Ramdas et al, 2015), were affected by both deletion and duplication events within exonic regions (Table S21). Knocking out the AHNAK gene in mice results in protection from diet-induced obesity, ADGRF5/GPR116 affects insulin sensitivity via modulation of adipose function (Nie et al, 2012), and ATP10D is involved in endoplasmic reticulum-to-Golgi ceramide processing and regulation of obesity (Kengia et al, 2013). These SVs might be correlated with that BMs are more unbearable to diabetogenic pressure compared with Durocs (Figures 2 and S2; Tables S2 and S3).…”

Lipid transport by Candida albicans Dnf2 is required for hyphal growth and virulence

“…Mutations in P4-ATPase genes are associated with a number of diseases and the fungal genes are becoming linked to pathogenesis. Human P4-ATPase mutations are linked to neurological disease (ATP8A2, ATP9A, ATP8B2, ATP10B, ATP11A), metabolic and cardiovascular disease (ATP10A, ATP10D), cholestasis and hearing loss (ATP8B1), systemic sclerosis (ATP8B4), severe Covid-19 (ATP11A), cancer progression (ATP11B) and hemolytic anemia (ATP11C) (22,23,(32)(33)(34)(35)(36)(37)(24)(25)(26)(27)(28)(29)(30)(31). The P4-ATPase Apt1-Cdc50 from Cryptococcus neoformans transports a variety of substrates, including GlcCer, and is essential in polysaccharide secretion, stress tolerance, fungal survival inside macrophages, and virulence (38)(39)(40)(41).…”