A general analytical platform and strategy in search for illegal drugs

Johansson, Monika; Fransson, Dick; Rundlöf, Torgny; Huynh, N. Van; Arvidsson, Torbjörn

doi:10.1016/j.jpba.2014.07.026

Cited by 47 publications

(32 citation statements)

References 20 publications

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“…Animal studies showed that phenolphthalein induced neoplasia in the ovary, atypical hyperplasia, hematopoietic cell proliferation, toxicity to the kidney and reproductive system in mice [22,23]. However, earlier studies also reported the presence of phenolphthalein as an adulterant in several illicit weight-loss supplements [24,25]. Both these compounds have been regarded unsafe in slimming products as their adverse effects outweigh their desired benefits [26].…”

Section: Discussionmentioning

confidence: 99%

Detection of Illicit Substances in Slimming Products Available in UAE

Alabdooli¹,

Js²,

Chandrasekaran³

et al. 2017

Journal of Nutrition and Health Sciences

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Section: Discussionmentioning

confidence: 99%

Detection of Illicit Substances in Slimming Products Available in UAE

Alabdooli¹,

Js²,

Chandrasekaran³

et al. 2017

Journal of Nutrition and Health Sciences

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“…This method detected Sibutramine along with other adulterants ( Figure 10); the concentration of Sibutramine detected in the capsule LIPO8 was 1mg. A measurement uncertainty of 1.5% was reported, with an S/N ratio of 150:1 or more; these two values were then applied as the LOQ (Johansson et al, 2014).…”

Section: Spectroscopic Methodsmentioning

confidence: 99%

“…Sibutramine detected at 1 mg/capsule. Detector: MS TOF; scan m/z 110-1000 scan rate 1s; centroid (Johansson et al, 2014) …”

Section: Spectroscopic Methodsmentioning

confidence: 99%

The Use of Analytical Techniques to Detect Toxic Synthetic Drug, Sibutramine, Adulterated in Traditional Herbal Medicines

Gadit¹,

Kandiah²

2017

International Conference on Bioscience and Biotechnology

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Traditional herbal medicines (THM's) are still being used worldwide in at least 80% of the population, mainly in developing countries, due to the assumption that they are safer and cheaper. However, these medicines are now being adulterated with synthetic drugs causing toxic effects. One such drug is Sibutramine, a drug used for weight loss. Although Sibutramine has several promising weight loss effects, it causes several toxic side effects; this resulted in its banning and withdrawal from the market. Despite this, it is still being adulterated in herbal medicines and needs to be detected. It is detected using several analytical techniques such as TLC, GC, LC-MS, LC-MS/MS, QTOF-LC/MS and more recently, spectroscopic techniques. Out of all the techniques, QTOF-LC/MS detected concentrations of Sibutramine adulterated in 9.4 mg (not clear what this means) and had LOD and LOQ values of 0.4-2.0 µg kg-1 and 1.3-6.0 µg kg-1 respectively; therefore, QTOF-LC/MS is the best technique developed up to date when compared to all the other techniques. However, research is currently ongoing to combine spectroscopic techniques other than MS, to overcome disadvantages such as lack of global information, false-positive results, time and labor consumption to detect Sibutramine adulteration in the future.

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“…Johansson et al [81] created an analytical platform using LC-QTOF-MS in combination with NMR spectroscopy to analyze unknown compounds in various types of herbal supplements. The World Health Organization (WHO) found that there were counterfeit products that had been falsely labeled and they either did not contain the APIs stated, or contained too little or too much, or had a different API all together [82].…”

Section: Hyphenated Techniquesmentioning

confidence: 99%

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2016

Planta Med

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A general analytical platform and strategy in search for illegal drugs

Cited by 47 publications

References 20 publications

Detection of Illicit Substances in Slimming Products Available in UAE

Detection of Illicit Substances in Slimming Products Available in UAE

The Use of Analytical Techniques to Detect Toxic Synthetic Drug, Sibutramine, Adulterated in Traditional Herbal Medicines

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