A general approach for teaching hydrolysis of salts

Aquirre-Ode, Fernando

doi:10.1021/ed064p957

Cited by 6 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This phenomenon can lead to spontaneous precipitation of the corresponding free acid or the free base form of the drug salt if the pH generated during dissolution is not sufficient to maintain solubility of the free acid or free base. [7][8][9] This paper will focus on the dissolution and precipitation mechanisms of soluble salts of poorly soluble basic drugs. Precipitation Mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…Occasionally, there are examples where the salt may have an even lower bioavailability than that of the parent drug. , The reason for the unpredictable bioavailability behavior of salts is due to the propensity of salts of poorly soluble drugs to undergo dissociation or “salt hydrolysis” upon contact with water in GI fluids. This phenomenon can lead to spontaneous precipitation of the corresponding free acid or the free base form of the drug salt if the pH generated during dissolution is not sufficient to maintain solubility of the free acid or free base. − This paper will focus on the dissolution and precipitation mechanisms of soluble salts of poorly soluble basic drugs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modifying the Diffusion Layer of Soluble Salts of Poorly Soluble Basic Drugs To Improve Dissolution Performance

Hawley

Morozowich

2010

Mol. Pharmaceutics

View full text Add to dashboard Cite

The dissolution mechanism of soluble salts of poorly soluble bases can be complex because both the dissolution of the salt and precipitation of the free base can occur depending on the experimental conditions and properties of the molecule. The dissolution of three soluble salts of poorly soluble bases is described in this paper. Two of these compounds precipitate as free base under normal stomach pH conditions (pH from 2-4) during dissolution. This free base precipitation is a result of formation of free base on the surface of the dissolving salt. Diffusion Layer modulated (DLM) solids are defined and presented that can effectively counteract this precipitation mechanism. These DLM materials employ excipients in order to modify the pH or solubility conditions at the surface of the dissolving salt to minimize precipitation of the free base that can occur. Rotating disk dissolution data is presented which shows how these formulated solids can act to improve the dissolution profile for these materials.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modifying the Diffusion Layer of Soluble Salts of Poorly Soluble Basic Drugs To Improve Dissolution Performance

Hawley

Morozowich

2010

Mol. Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…A scientific paper proposing a fruitful approach to teach acid-base properties of salt solution is found from the work of Aquirre-Ode (1987). Similar work following this paper has not been found.…”

mentioning

confidence: 81%

Uncovering Students' Understanding; Evidence For The Teaching of Acid-Base Properties of Salt Solution

et al. 2022

View full text Add to dashboard Cite

<p>Este estudio tuvo como objetivo descubrir la comprensión científica y no científica de los estudiantes sobre el tema de las propiedades ácido-base de la solución salina. Este estudio descriptivo involucró a 300 estudiantes de tres escuelas secundarias públicas en Malang, Java Oriental, Indonesia. El instrumento de cuatro niveles en el tema desarrollado y considerado válido de nuestro trabajo anterior se utilizó para la recopilación de datos. Se encuentra que la comprensión científica de algunos conceptos por parte de los estudiantes es sólida. Sin embargo, también se descubrieron algunos conocimientos no científicos. También se discute la implicación para la enseñanza del tema.</p>

show abstract

Successive‐substitution methods in chemical‐equilibrium calculations: An application to aqueous simple ampholytic electrolytes

Cardinali¹,

Giomini²,

Marrosu³

1996

Bulletin des Soc Chimique

View full text Add to dashboard Cite

For each of the aqueous electrolytes, whose acid-base behaviour is described by only one acidic, and only one basic, ionization equilibrium, the electroneutrality equation is rearranged (as described in Appendix) to such a form that the successive-substitution algorithm to which it can give origin always converges to the root of the corresponding equation, i. e., to the hydrogen-ion concentration of the solution it refers to. The converging properties of these algorithms are given a qualitative explanation. IntroductionRecently, this Journal published a paper of ours(') concerning the interval-bisection method applied to the calculation of the concentration of the hydrogen ion (and the other species) occurring in aqueous solutions of various classes of simple ampholytic electrolytes, i.e., those electrolytes whose acid-base behaviour is described by only one acidic, and only one basic,

show abstract

A general approach for teaching hydrolysis of salts

Cited by 6 publications

References 0 publications

Modifying the Diffusion Layer of Soluble Salts of Poorly Soluble Basic Drugs To Improve Dissolution Performance

Modifying the Diffusion Layer of Soluble Salts of Poorly Soluble Basic Drugs To Improve Dissolution Performance

Uncovering Students' Understanding; Evidence For The Teaching of Acid-Base Properties of Salt Solution

Successive‐substitution methods in chemical‐equilibrium calculations: An application to aqueous simple ampholytic electrolytes

Contact Info

Product

Resources

About