A general Fe-catalysed azidation of iododifluoroketones and its utilization for the synthesis of gem-difluoromethylenated triazoles

Abstract

An iron-catalysed radical azidation of iododifluoroketones with TMSN3 has been developed under mild reaction conditions, providing a concise synthesis of α-difluoroalkylazides. The methyl radical generated from tert-butyl peroxybenzoate enables the...

Visible Light-Induced Copper-Catalyzed Regio- and Stereoselective Difluoroalkylthiocyanation of Alkynes

“…However, the corresponding transformation of alkynes by this attractive catalytic system has not been documented. As part of our continuing interest in the chemistry of di­(mono)­fluoroalkylation, we herein report a visible light-induced copper-catalyzed regio- and stereoselective difluoroalkylthiocyanation of alkynes with BrCF 2 R and KSCN to afford CF 2 -derived multisubstituted alkenes (Scheme d). The photosensitizer formed in situ from copper and a phosphine ligand not only promotes the generation of CF 2 -alkyl radicals but also aids in the formation of C–SCN bonds, allowing the reaction to proceed smoothly in the absence of any additional photocatalysts and radical initiators.…”