A General Method to Access Sterically Encumbered Geminal Bis(boronates) via Formal Umpolung Transformation of Terminal Diboron Compounds
Peng‐Fei Ning,
Yi Wei,
Xin‐Yi Chen
et al.
Abstract:General methods for the preparation of geminal bis(boronates) are of great interest due to their widespread applications in organic synthesis. While the terminal gem‐diboron compounds are readily accessible, the construction of the sterically encumbered, internal analogues has remained a prominent challenge. Herein, we report a formal umpolung strategy to access these valuable building blocks. The readily available 1,1‐diborylalkanes were first converted into the corresponding α‐halogenated derivatives, which … Show more
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