The present study was conducted to present the comparative modeling, predictive and generalization abilities of response surface methodology (RSM) and artificial neural network (ANN) for the thermal structure of stabilized confined jet diffusion flames in the presence of different geometries of bluff-body burners. Two stabilizer disc burners tapered at 30˚ and 60˚ and another frustum cone of 60˚/30˚ inclination angle were employed all having the same diameter of 80 (mm) acting as flame holders. The measured radial mean temperature profiles of the developed stabilized flames at different normalized axial distances () j x d were considered as the model example of the physical process. The RSM and ANN methods analyze the effect of the two operating parameters namely () r , the radial distance from the center line of the flame, and () j x d on the measured temperature of the flames, to find the predicted maximum temperature and the corresponding process variables. A three-layered Feed Forward Neural Network in conjugation with the hyperbolic tangent sigmoid (tansig) as transfer function and the optimized topology of 2:10:1 (input neurons: hidden neurons: output neurons) was developed. Also the ANN method has been employed to illustrate such effects in the three and two dimensions and shows the location of the predicted maximum temperature. The results indicated the superiority of ANN in the prediction capability as the ranges of R 2 and F Ratio are 0.868-0.947 and 231.7-864.1 for RSM method compared to 0.964-0.987 and 2878.8 7580.7 for ANN method beside lower values for error analysis terms.