A general practice study of flurbiprofen sustained‐release

Pf, Boston; Constad, D

doi:10.1111/j.1742-1241.1988.tb08506.x

Int J Clinical Practice

1988

DOI: 10.1111/j.1742-1241.1988.tb08506.x

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A general practice study of flurbiprofen sustained‐release

Boston Pf

D Constad²

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1992

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A comparison of upper gastrointestinal mucosal damage by standard and delayed‐release indomethacin

Swift

Arnold²,

Williams

et al. 1992

Aliment Pharmacol Ther

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S U M M A R YForty-five patients taking long-term indomethacin and with endoscopic erosions or superficial ulcers in the oesophagus, stomach or duodenal bulb were randomized in a double-blind study to continue with standard indomethacin or receive a ' delayed-release' formulation. This consisted of microgranules of indomethacin coated with an acrylic resin, Eudragit L, which releases drug in the small intestine. Endoscopy was repeated after 8 weeks and biopsies taken on both occasions. Changes in endoscopic lesions and histological appearances were similar in both groups, although mucosal erythema was less in those given Eudragit L indomethacin. Systemic, rather than topical, effects of indomethacin may therefore be responsible for persistence of gastro-duodenal mucosal lesions in these patients. There is reason to question the clinical practice of using expensive, delayed-release preparations.

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A comparison of upper gastrointestinal mucosal damage by standard and delayed‐release indomethacin

Swift

Arnold²,

Williams

et al. 1992

Aliment Pharmacol Ther

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show abstract

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A general practice study of flurbiprofen sustained‐release

Cited by 1 publication

References 3 publications

A comparison of upper gastrointestinal mucosal damage by standard and delayed‐release indomethacin

A comparison of upper gastrointestinal mucosal damage by standard and delayed‐release indomethacin

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