A general strategy for one-step fabrication of biocompatible microcapsules with controlled active release

Sun, Zeyong; Yang, Chenjing; Eggersdorfer, Maximilian L.; Cui, Jiecheng; Li, Yiwei; Ming, Hai; Chen, Dong; Weitz, David A.

doi:10.1016/j.cclet.2019.04.040

Cited by 37 publications

(30 citation statements)

References 29 publications

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“…In general, there are four possible morphologies for the two-phase system: core-shell, occluded, acorn and heteroaggregate, while the final morphology is determined by the energy minimum and could be predicted by the spreading coefficients. [42][43][44][45] To calculate the spreading coefficients, the interfacial tension of solid and liquid is derived from Young's equation  SL = SG -cos LG , where  SL ,  SG and  LG are the solid/liquid, solid/gas and liquid/gas interfacial tensions, respectively, as shown in Figure 2b; we obtain  os~4 mN/m and  sw~6 mN/m, where  os and  sw are the oil/shellac and shellac/water interfacial tensions, respectively. The oil/water interfacial tension  ow measured by pendent drop experiments is  ow~2 2 mN/m and we get S 1 = ow -( os + sw )>0, S 2 = os -( ow + sw )<0 and S 3 = sw -( os + ow )<0.…”

Section: Resultsmentioning

confidence: 99%

Active Encapsulation in Biocompatible Nanocapsules

Yang

et al. 2020

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Co-precipitation is generally referred to the co-precipitation of two solids and is widely used to prepare active-loaded nanoparticles. Here, we demonstrate that liquid and solid could precipitate simultaneously to produce hierarchical core-shell nanocapsules that encapsulate an oil core in a polymer shell. During the co-precipitation process, the polymer preferentially deposits at the oil/water interface, wetting both the oil and water phases; the behavior is determined by the spreading coefficients and driven by the energy minimization. The technique is applicable to directly encapsulate various oil actives and avoid the use of toxic solvent or surfactant during the preparation process. The obtained core-shell nanocapsules harness the advantage of biocompatibility, precise control over the shell thickness, high loading capacity, high encapsulation efficiency, good dispersity in water and improved stability against oxidation. The applications of the nanocapsules as delivery vehicles are demonstrated by the excellent performances of natural colorant and anti-cancer drug-loaded nanocapsules. The core-shell nanocapsules with a controlled hierarchical structure are, therefore, ideal carriers for practical applications in food, cosmetic and drug delivery.Received: ((will be filled in by the editorial staff))Revised: ((will be filled in by the editorial staff)) Published online: ((will be filled in by the editorial staff)) nanocapsules (blue columns), suggesting that the nanocapsules are biocompatible and are ideal carriers for anti-cancer drugs.Hierarchical core-shell nanocapsules are developed by controlled co-precipitation and phase separation. The core-shell nanocapsules serve as excellent delivery vehicles and possess tunable shell thickness, high encapsulation efficiency, high loading capacity, good dispersity in water, improved stability and pH-triggered release, which opens a door to a range of new applications in food, cosmetic and drug delivery.

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Section: Resultsmentioning

confidence: 99%

Active Encapsulation in Biocompatible Nanocapsules

Yang

et al. 2020

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“…The preparation of microcapsules by microfluidics generally use single emulsions as templates or double emulsions as templates. When using single emulsions as templates, the microcapsules are prepared by the controlled phase separation of the polymer upon solvent evaporation [79,80] . Tang et al.…”

Section: Applicationsmentioning

confidence: 99%

“…When using single emulsions as templates, the microcapsules are prepared by the controlled phase separation of the polymer upon solvent evaporation. [79,80] Tang et al used a flow-focusing microfluidics device and prepared uniform droplets of oil and polymer in chloroform. Upon fast solvent evaporation, the polymer phase Figure 3.…”

Section: Applications Of Core-shell Capsulesmentioning

confidence: 99%

Diverse Particle Carriers Prepared by Co‐Precipitation and Phase Separation: Formation and Applications

Sun

Ren

et al. 2020

ChemPlusChem

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Nanoparticles with diverse structures and unique properties have attracted increasing attention for their widespread applications. Co‐precipitation under rapid mixing is an effective method to obtained biocompatible nanoparticles and diverse particle carriers are achieved by controlled phase separation via interfacial tensions. In this Minireview, we summarize the underlying mechanism of co‐precipitation and show that rapid mixing is important to ensure co‐precipitation. In the binary polymer system, the particles can form four different morphologies, including occluded particle, core‐shell capsule, dimer particle, and heteroaggregate, and we demonstrate that the final morphology could be controlled by surface tensions through surfactant, polymer composition, molecular weight, and temperature. The applications of occluded particles, core‐shell capsules and dimer particles prepared by co‐precipitation or microfluidics upon the regulation of interfacial tensions are discussed in detail, and show great potential in the areas of functional materials, colloidal surfactants, drug delivery, nanomedicine, bio‐imaging, displays, and cargo encapsulation.

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“…Emulsions that consist of one phase dispersed in another phase have been widely used in food, cosmetics, drug delivery, biomedicine, catalysts, and materials . Stabilization of the emulsions generally requires the addition of surfactants.…”

Section: Figurementioning

confidence: 99%

Biocompatible and pH‐Responsive Colloidal Surfactants with Tunable Shape for Controlled Interfacial Curvature

et al. 2020

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Molecular‐surfactant‐stabilized emulsions are susceptible to coalescence and Ostwald ripening. Amphiphilic particles, which have a much stronger anchoring strength at the interface, could effectively alleviate these problems to form stable Pickering emulsions. Herein, we describe a versatile method to fabricate biocompatible amphiphilic dimer particles through controlled coprecipitation and phase separation. The dimer particles consist of a hydrophobic PLA bulb and a hydrophilic shellac–PEG bulb, thus resembling nonionic molecular surfactants. The size and diameter ratio of the dimer particles are readily tunable, providing flexible control over the water/oil interfacial curvature and thus the type of emulsion. The particle‐stabilized emulsions were stable for a long period of time and could be destabilized through a pH‐triggered response. The biocompatible amphiphilic dimer particles with tunable morphology and functionality are thus ideal colloidal surfactants for various applications.

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A general strategy for one-step fabrication of biocompatible microcapsules with controlled active release

Cited by 37 publications

References 29 publications

Active Encapsulation in Biocompatible Nanocapsules

Active Encapsulation in Biocompatible Nanocapsules

Diverse Particle Carriers Prepared by Co‐Precipitation and Phase Separation: Formation and Applications

Biocompatible and pH‐Responsive Colloidal Surfactants with Tunable Shape for Controlled Interfacial Curvature

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