A General Synthesis of (±)-γ-Substituted γ-Butyrolactones Using a Kinetic Alkylation-Ozonolysis Procedure

Supercritical Carbon Dioxide as a Reaction Medium for Silane-Mediated Free-Radical Carbonylation of Alkyl Halides

“…Methyl 4-oxododecanoate (3b): 1 H NMR (300 MHz, CDCl 3 ) δ 3.62 (s, CH 3 O, 3H), 2.67 (t, COC H 2 CH 2 COO, 2H), 2.53 (t, COCH 2 C H 2 COO, 2H), 2.39 (t, C H 2 COCH 2 CH 2 COO, 2H), 1.53 (m, CH 3 (CH 2 ) 5 C H 2 CH 2 CO, 2H), 1.22 (br s, CH 3 (C H 2 ) 5 CH 2 CH 2 CO, 10H), 0.82 (t, CH 3 , 3H); 13 C{ 1 H} NMR (75.45 MHz, CDCl 3 ): δ 209.0, 173.2, 51.6, 42.7, 36.9, 31.7, 29.3, 29.1, 29.0, 27.6, 23.7, 22.5, 14.0. These spectroscopic data were consistent with those previously reported …”