The Vehicle Energy Consumption calculation Tool (VECTO) is used in Europe for calculating standardised energy consumption and CO2 emissions from Heavy-Duty Trucks (HDTs) for certification purposes. The tool requires detailed vehicle technical specifications and a series of component efficiency maps, which are difficult to retrieve for those that are outside of the manufacturing industry. In the context of quantifying HDT CO2 emissions, the Joint Research Centre (JRC) of the European Commission received VECTO simulation data of the 2016 vehicle fleet from the vehicle manufacturers. In previous work, this simulation data has been normalised to compensate for differences and issues in the quality of the input data used to run the simulations. This work, which is a continuation of the previous exercise, focuses on the deeper meaning of the data received to understand the factors contributing to energy and fuel consumption. Fuel efficiency distributions and energy breakdown figures were derived from the data and are presented in this work. Correlation formulas were produced to calculate the energy loss contributions of individual components and resistances (air drag, rolling resistance, axle losses, gearbox losses, etc.) over the Regional Delivery and Long Haul cycles, given a limited number of input parameters such as vehicle characteristics and average component efficiencies. Default values and meaningful ranges of variation of these parameters obtained from the data of the fleet are also reported in this work. The importance of air drag and rolling resistance losses are highlighted since these losses account for about 70% of the energy consumed downstream the engine. Finally, based on the correlation formulas to calculate the individual energy losses, a method is presented that calculates the final energy consumption and CO2 emissions for all the regulated HDTs classes and that does not rely on the use of VECTO.