2019
DOI: 10.1101/654913
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

A Generalized Similarity Metric for Predicting Peptide Binding Affinity

Abstract: 22 42 of among the peptides with different sequences and lengths in a wide range of 43 biotechnology, nanomedicine and bioinformatics applications.44 45 46

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
0
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
1
1

Relationship

1
1

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 41 publications
0
0
0
Order By: Relevance
“…[14,16] The specific amino acid sequence of the WT peptide represents a biological entity that is selected to bind to graphite [18] whose binding could not be otherwise designed using, e.g., computational modeling [48] or predicted by using machine intelligence. [49] An important characteristic of these peptides is that they do not normally interact with each other within the aqueous solution, a part of their specific characteristics of binding to the solid substrate, i.e., individual, standalone peptide molecule has unique recognition characteristics. [14] This suggests that the solid surface interaction within the aqueous conditions takes precedent over intermolecular interactions, especially among the peptides solubilized within the solution, a key consequence of the genetic selection procedure.…”
Section: Discussionmentioning
confidence: 99%
“…[14,16] The specific amino acid sequence of the WT peptide represents a biological entity that is selected to bind to graphite [18] whose binding could not be otherwise designed using, e.g., computational modeling [48] or predicted by using machine intelligence. [49] An important characteristic of these peptides is that they do not normally interact with each other within the aqueous solution, a part of their specific characteristics of binding to the solid substrate, i.e., individual, standalone peptide molecule has unique recognition characteristics. [14] This suggests that the solid surface interaction within the aqueous conditions takes precedent over intermolecular interactions, especially among the peptides solubilized within the solution, a key consequence of the genetic selection procedure.…”
Section: Discussionmentioning
confidence: 99%