In the design of reinforced concrete (RC) bridges, the random and nonlinear behavior of soil may lead to insufficient reliability levels. For this reason, it is necessary to take into account the variability of soil properties which can significantly affect the bridge behavior regarding ultimate and serviceability limit states. This study investigates the failure probability for existing reinforced concrete bridges due to the effects of interaction between the soil and the structure. In this paper, a coupled reliability-mechanical approach is developed to study the effect of soil-structure interaction for RC bridges. The modeling of this interaction is incorporated into the mechanical model of RC continuous beams, by considering nonlinear elastic soil stiffness. The reliability analysis highlights the large importance of soil-structure interaction and shows that the structural safety is highly sensitive to the variability of soil properties, especially when the nonlinear behavior of soil is considered. Ó 2015 Faculty of Engineering, Ain Shams University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).