The Star Trek franchise’s depiction of artificial intelligence (AI) and affiliated technologies—namely, supercomputers, androids, and holograms—evokes common themes and motifs from the myths of the ancient Mediterranean. This article analyzes the mythological underpinnings of Star Trek’s historical treatment and approach to AI, from The Original Series to The Next Generation and up through the newest additions to the canon, Short Treks, and Picard. AI in Star Trek, like Data, the Doctor, and Zora, expresses qualities associated with divinity: superhuman strength, intelligence, and agelessness. These very qualities distinguish them from humans and bar them from considerations of personhood. Like the Greek gods of myth, AI can present as immortal, which fundamentally distinguishes it from mortal humans, as seen in the tensions between gods and humans in Homer’s Odyssey and the Homeric Hymns. The ancient tension between mortal and immortal is manifested in the combative relationship between organic creator and artificial creation, a common sci-fi trope, that can lead to a cycle of fear and hostility evocative of the divine generational warfare in Hesiod’s Theogony. The artificial–organic tension resonates with the contemporary audience’s conflicted experiences with evolving technologies and problematizes the show’s presentation of the evolution of humanity into a posthuman existence. Just as mythology is used to consider humanity relative to the divine, narratives about AI are fertile ground to analyze what it means to be human and establish parameters for what is decidedly not human.