A genetic analysis of crystal growth 1 1Edited by M. Gottesman

Brown, Stanley; Sarıkaya, Mehmet; Johnson, Erik

doi:10.1006/jmbi.2000.3682

Cited by 345 publications

(317 citation statements)

References 28 publications

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“…[1][2][3][4][5][6][7][8][9][10][11] Peptides have also been shown to act as stabilizers, reducing agents, catalysts or inhibitors when incorporated in solution syntheses of inorganic materials. 10,12,13 Great prospects lie in the use of material binding peptides to improve artificial material formation processes following more environmentally sustainable bioinspired methods.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Study of Interactions Between ZnO and ZnO Binding Peptides Using Isothermal Titration Calorimetry

Limo

Perry

2015

Langmuir

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Whilst material specific peptide binding sequences have been identified using a combination of combinatorial methods and computational modelling tools, a deep molecular level understanding of the fundamental principles through which these interactions occur and in some instances modify the morphology of inorganic materials is far from being fully realized. Understanding the thermodynamic changes that occur during peptide-inorganic interactions and correlating these to structural modifications of the inorganic materials could be the key to achieving and mastering control over material formation processes. This study is a detailed investigation applying isothermal titration calorimetry (ITC) to directly probe thermodynamic changes that occur during interaction of ZnO binding peptides (ZnO-BPs) and ZnO. The ZnO-BPs used are reported sequences G-12 (GLHVMHKVAPPR), GT-16 (GLHVMHKVAPPR-GGGC) and alanine mutants of G-12 (G-12A6, G-12A11 and G-12A12) whose interaction with ZnO during solution synthesis studies have been extensively investigated. The interactions of the ZnO-BPs with ZnO yielded biphasic isotherms comprising both an endothermic and an exothermic event. Qualitative differences were observed in the isothermal profiles of the different peptides and ZnO particles studied. Measured ∆G values were between -6 and -8.5 kcal/mol and high adsorption affinity values indicated the occurrence of favourable ZnO-BP-ZnO interactions. ITC has great potential in its use to understand peptide-inorganic interactions and with continued development, the knowledge gained may be instrumental for simplification of selection processes of organic molecules for the advancement of material synthesis and design.

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Section: Introductionmentioning

confidence: 99%

Thermodynamic Study of Interactions Between ZnO and ZnO Binding Peptides Using Isothermal Titration Calorimetry

Limo

Perry

2015

Langmuir

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“…These approaches have been adapted to select peptides that bind to solid inorganic materials. 1,[3][4][5][6][7][8][9][55][56][57][58][59]66 The articles by Evans et al and Tomczak et al in this issue explain combinatorial mutagenesis, the method of creating a large set of phage or bacteria-each displaying a peptide with a random sequence-and the biopanning process, the method that culls the set to obtain only the peptide sequences that selectively bind The enamel has an architecture of woven enamel rods (3 µm diameter) at the micrometer scale, each rod containing thousands of long HA crystallites (10s of nm thick and several mm long), all spatially and crystallographically well-organized on the nanometer scale.…”

Section: Selection Of Inorganic-binding Peptides Using Combinatorial mentioning

confidence: 99%

“…Peptides have desirable inorganic-binding and assembly characteristics and can be used as molecular building blocks in practical applications. [2][3][4][5][6] The peptides work either in isolation or when inserted within the structural framework of designer proteins (such as enzymes) that have useful characteristics. The central premise of this interdisciplinary field is that genetically engineered peptides for inorganics (GEPIs) 1 can be utilized as molecular erector sets.…”

Section: Introductionmentioning

confidence: 99%

“…The central premise of this interdisciplinary field is that genetically engineered peptides for inorganics (GEPIs) 1 can be utilized as molecular erector sets. [2][3][4][5][6] With molecular biomimetics methods, peptides may direct synthesis, fabrication, assembly, and architecture of hybrid materials, creating materials with programmed composition, phase, and topology. Such materials could have designed and controlled functions at the molecular or nanometer scale.…”

Section: Introductionmentioning

confidence: 99%

“…The peptide fabrication and assembly processes take place under ambient and environmentally friendly conditions. [1][2][3][4][5][6][7][8][9][10][11] Gaining the ability to closely manipulate the behavior of peptides to fully control materials formation would be a giant leap toward realizing nanometer-scale building blocks that tailor electronic, optical, mechanical, or magnetic materials properties. 25 Molecular biology and genetics approaches could modify the polypeptides and their molecular-recognition characteristics, [11][12][13][14][15] and traditional and state-of-the-art engineering approaches 16 could create inorganic or synthetic structures such as nanoparticles, [17][18][19][20] quantum dots, 20 molecular wires 21 or nanowires, 22 or synthetic molecular systems 23 (e.g., organic semiconductors).…”

Section: Introductionmentioning

confidence: 99%

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Molecular Biomimetics: Genetic Synthesis, Assembly, and Formation of Materials Using Peptides

Tamerler¹,

Sarıkaya²

2008

MRS Bull.

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In nature, the molecular-recognition ability of peptides and, consequently, their functions are evolved through successive cycles of mutation and selection. Using biology as a guide, it is now possible to select, tailor, and control peptide-solid interactions and exploit them in novel ways. Combinatorial mutagenesis provides a protocol to genetically select short peptides with specific affinity to the surfaces of a variety of materials including metals, ceramics, and semiconductors. In the articles of this issue, we describe molecular characterization of inorganic-binding peptides; explain their further tailoring using post-selection genetic engineering and bioinformatics; and finally demonstrate their utility as molecular synthesizers, erectors, and assemblers. The peptides become fundamental building blocks of functional materials, each uniquely designed for an application in areas ranging from practical engineering to medicine.

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